Results of histological evaluation of glandular epithelium in BPH in hypo- and eugonadal men

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Abstract

Introduction. Benign prostatic hyperplasia (BPH), despite advances in pharmacotherapy and surgical treatment, remains a pressing problem in modern urology. The success of therapy depends on the condition of the prostate epithelial compartment.

Objective. To conduct a histological assessment of glandular epithelium in BPH in hypo- and eugonadal men.

Materials and methods. The results of morphological examination of the resected prostate tissue of 188 men with BPH were analyzed, who were divided into two groups: Group I – 71 patients with testosterone (Tc) deficiency, group II (control) – 117 patients with testosterone levels above 12.1 nmol/L.

Results. In patients with Tc deficiency, morphological examination of resected prostate tissue samples revealed a stromal pattern of BPH, combined with cystic deformation of the acini, with flattened and non-secretory epithelium. In patients with normal Tc levels, all patients had a glandular pattern of hyperplasia, and the epithelial cells of the acini were tall, columnar, and showed signs of active secretion.

Conclusions. In patients with testosterone deficiency, morphological examination of resected prostate tissue samples revealed atrophic, flattened, and non-secretory epithelium.

In patients with Tc levels within the reference range, all epithelial cells were tall, columnar, and showed signs of active secretion.

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About the authors

Magomed-Khadzhi Magomedovich Uzhakhov

Rostov State Medical University, Ministry of Health of the Russian Federation

Email: magamaas@mail.ru
ORCID iD: 0000-0001-7912-2649

postgraduate student of the Department of Urology and Human Reproductive Health (with a course of pediatric urology and andrology)

Russian Federation, Rostov-on-Don

Svetlana I. Lemeshko

GBU RO KDC «Health»

Email: lemeshko_lana@mail.ru
ORCID iD: 0009-0003-0431-7902

Candidate of Medical Sciences, morphologist

Russian Federation, Rostov-on-Don

Khalid Suleimanovich Ibishev

Rostov State Medical University, Ministry of Health of the Russian Federation

Author for correspondence.
Email: Ibishev22@mail.ru
ORCID iD: 0000-0002-2954-842X

Doctor of Medical Sciences, Professor of the Department of Urology and Human Reproductive Health (with a course of pediatric urology and andrology)

Russian Federation, Rostov-on-Don

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Supplementary files

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2. Fig. 1. The epithelium of the acinar structures is atrophic. The stromal component is prominent. Glandular proliferation is absent. Single muscular elements. Stained with hematoxylin and eosin. Magnification x100.

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3. Fig. 2. Stromal proliferation. Atrophy of the secretory epithelium. Hematoxylin and eosin staining. Magnification x100

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4. Fig. 3. Stromal proliferation. Atrophy of the secretory epithelium. Hematoxylin and eosin staining. Magnification x100

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5. Fig. 4. Stromal proliferation. Epithelial cells are flattened and non-secretory. Hematoxylin and eosin stain. Magnification x200.

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6. Fig. 5. Glandular hyperplasia. Marked hyperplasia of acinar structures. The glandular component predominates over the stromal component. Secretory epithelial cells are tall. Stained with hematoxylin and eosin. Magnification x400.

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7. Fig. 6. Glandular hyperplasia. Secretory epithelium lining the inner surface of the glands is tall, columnar, and shows signs of secretion. Hematoxylin and eosin staining. Magnification x100.

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