Anogenital warts: a new way of solving the common problem of urology (results of long-term follow-up)


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Abstract

Aim To evaluate the effectiveness of combined use of the imiquimod 5% cream and vaccination against human papillomavirus (HPV) using a quadrivalent recombinant vaccine to achieve long-term clinical remission of chronic HPV infection manifested by anogenital warts. Material and methods The study comprised 36 patients, including 22 men, aged 26.4±4.1 years, who had from 1 to 5 anogenital warts. Participants of the study were vaccinated by quadrivalent recombinant vaccine under a 3-dose scheme 0-2-6 months co-administered with imiquimod 5% cream three times per week up to 16 weeks. The follow-up period was 2 years. Results Complete disappearance of genital warts within 1 year from baseline was observed in 34 (94.4%) patients. Two patients with anogenital warts after 1 year were treated for 1 year 3 months and 1 year and 4 months with Solcoderm which lead to the complete disappearance of genital warts. There were no recurrences of genital warts during the 2 years of follow-up. Conclusion Vaccination with a recombinant quadrivalent vaccine concurrently with using imiquimod 5% cream results in prolonged clinical remission of chronic HPV infection manifested by anogenital warts in at least 94.4% of the cases (2 year follow-up).

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About the authors

A. D Protasov

Samara State Medical University

Email: crosss82@maiI.ru
PhD, Associate Professor at the Department of General and Clinical Microbiology, Immunology and Allergology, SamSMU, Allergist-Immunologist at the Clinic SamSMU

I. S Lipatov

Samara State Medical University

Email: i.lipatoff2012@yandex.ru

M. P Kostinov

I.I. Mechnikov Research Institute of Vaccines and Sera

Email: vaccine@bk.ru

Yu. V Tezikov

Samara State Medical University

Email: yra.75@inbox.ru

A. D Shmit’ko

I.I. Mechnikov Research Institute of Vaccines and Sera

Email: violadellanna@gmail.com

D. V Pakhomov

I.I. Mechnikov Research Institute of Vaccines and Sera

Email: vaccine@bk.ru

D. A Blagovidov

I.I. Mechnikov Research Institute of Vaccines and Sera

Email: vaccine@bk.ru

A. V Zhestkov

Samara State Medical University

Email: avzhestkov2015@yandex.ru

A. A Ryzhov

I.I. Mechnikov Research Institute of Vaccines and Sera

Email: vaccine@bk.ru

E. V Vekhova

Samara Regional Center for Prevention and Control of AIDS and Infectious Diseases

References

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