Evidence-based study of kidney transplantation: renal arterial resistance and rejection

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Abstract

Background: To decrease the high morbidity and mortality of patients with end-stage renal disease kidney transplantation is the most effective management.

This study aimed to investigate changes in clinical, biochemical, inflammation, rejection, and its association with the renal arterial resistive index after kidney transplantation.

Methods: In this study, we assessed changes in clinical, biochemical, and renal arterial resistive (RRI) index measured by doppler ultrasound and its association with graft rejection after kidney transplantation in 60 adult recipients. Data included; gender, age, hospital stay, living or deceased donor, evidence of acute tubular necrosis, donor (living or cadaver), preference of vessel anastomosis (first artery- second vein; FASV or FVSA), preference of arterial anastomosis (as end-to-end to hypogastric artery or end-to-side to common or external iliac artery), evidence for acute tubular necrosis (ATN), in addition to biochemical variables were noted analyzed by SPSS.

Results: With a minimum of 16 and a maximum of 68, the mean±SD was 42,3±13,7 years old. Of the total population studied 52% received kidneys from cadaver donors. Although acute tubular necrosis versus acute rejection was reported at 32% versus 60%, the value of RRI in the total population was 0,76±0,11. There was a significant difference in rejected versus non-rejected (p=0,001) and living versus cadaver donors regarding the values of reported RRI (р=0,018).

Conclusion: In this study, the recorded RRI suggested respected information regarding changes within intraparanchymal vascularization linked to rejection after kidney transplantation. Further evidence-based studies regarding RRI with more sample size are recommended.

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About the authors

Zahra Tolou-Ghamari

Nutrition and Food Security Research Center, Deputy of Research and Technology, Isfahan University of Medical Sciences

Author for correspondence.
Email: toloeghamari@pharm.mui.ac.ir

Deputy of Research and Technology

Iran, Islamic Republic of, Isfahan

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