Intraprostatic injection of 96% ethanol in animal experiment
- Авторлар: Martov LG1, Pavlov DA1, Kirpatovsky VI1, Kudryavtsev Y.V1
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Мекемелер:
- Шығарылым: № 6 (2004)
- Беттер: 21-26
- Бөлім: Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/276238
- ID: 276238
Дәйексөз келтіру
Толық мәтін
Аннотация
Transurethral intraprostatic injection of ethanol (HE) is a new
low-invasive method in the treatment of benign prostatic hyperplasia
(BPH). We made dog and rat experiments to prove safety and efficacy
of HE. The experiment was made on 10 rats and 10 dogs injected
transurethrally (Prostaject device) with 96% ethyl alcohol in 10% volume
of estimated volume of the prostate. The injection was followed
by measurement of blood alcohol, the test for hemolysis. Transurethral
ultrasound control of prostate size 1, 3 and 6 months after the
injection and histological examinations 1, 3, 7, 14 days and 1, 3 and
6 months after the injection were made. It was found that blood alcohol
after the above injection was not elevated. Necrosis was documented
in all the cases but subsequently the necrotic site was replaced
with sclerotic tissue. The necrosis involved only the prostatic capsule.
The size of the prostate diminished by 29%. Thus, transurethral injection
of ethyl alcohol (10% of prostate size) is safe and effective in
achievement of prostatic gland ablation. Therefore, clinical trials of
the method in patients with benign prostatic hyperplasia are justified
low-invasive method in the treatment of benign prostatic hyperplasia
(BPH). We made dog and rat experiments to prove safety and efficacy
of HE. The experiment was made on 10 rats and 10 dogs injected
transurethrally (Prostaject device) with 96% ethyl alcohol in 10% volume
of estimated volume of the prostate. The injection was followed
by measurement of blood alcohol, the test for hemolysis. Transurethral
ultrasound control of prostate size 1, 3 and 6 months after the
injection and histological examinations 1, 3, 7, 14 days and 1, 3 and
6 months after the injection were made. It was found that blood alcohol
after the above injection was not elevated. Necrosis was documented
in all the cases but subsequently the necrotic site was replaced
with sclerotic tissue. The necrosis involved only the prostatic capsule.
The size of the prostate diminished by 29%. Thus, transurethral injection
of ethyl alcohol (10% of prostate size) is safe and effective in
achievement of prostatic gland ablation. Therefore, clinical trials of
the method in patients with benign prostatic hyperplasia are justified
Әдебиет тізімі
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