INTRAVESICAL IONOPHORESIS OF MEDICINES (ANEXPERIMENTAL STUDY)

Аннотация

The depth of drug penetration into the wall of the urinary bladder
in intravesical ionophoresis (IVIP), IVIP influence on functional condition
of the lower urinary tracts were studied on 15 female dogs.
Functional condition of the lower urinary tracts was characterized by
pressure in the urinary bladder, "volume-pressure" index, bioelectric
activity of the urethra. The pressure was registered by electromanometry.
Bioelectric activity of the urethra was studied with electromyography
and tetrapolar rheography. The above indices were registered
synchroneously on a multichannel recorder. Intraoperative cystomanometry
was made in 7 tyopental narcotized animals. Samples of
blood and vesicular tissue were taken for immunofluorescent study
before and after IVIP. Medicines were accumulated best in mucous
and submucous layers (0.03910.0012 and 0.0338±0.0050 mcm/mg
tissue, respectively). After IVIP intravesical pressure was, on the average,
lower in the same filling volumes as before IVIP. A mean amplitude
of spontaneous fluctuations of pressure in the urinary bladder
in its filling after IVIP was also lower than the baseline. After IVIP,
pressure in the urinary bladder in voiding was much lower than before
the procedure, maximal capacity of the urinary bladder and elasticity
of the wall increased. Bioelectrical activity of the urethral wall was
registered in the same mean pressure and capacity as before IVIP. Intensity
of micturition after IVIP course decreased both at rest and in
diuretic load with lasix. Time to micturition was increased with an
increase in the number of procedures of IVIP. Thus, the experimental
study showed pathogenetic validity of intravesical ionophoresis of
medicines in the treatment of chronic recurrent cystitis