Clinical significance of PET/CT molecular cell diagnostics of inflammatory diseases of the urinary system

Мұқаба

Дәйексөз келтіру

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Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Introduction. The formation of a local pathological process is associated with a disturbance of functional molecular bonds both inside the cell and in the intercellular space surrounding it. It precedes the appearance of laboratory and clinical manifestations of the disease and is available for non-invasive analysis only by PET/CT scanning.

Aim. To determine the clinical significance of PET/CT scanning in molecular cell diagnosis of inflammatory diseases of the urinary system.

Materials and methods. A comparative study of the results of whole-body PET/CT with 11C-choline and 18F-FDG glucose was carried out with a comparison with the results of kidney and bladder morphobiopsy in 96 urological patients, including 56 women and 40 men with a median age of 51.5 (37; 61). They were randomized into three equal groups: without clinical and laboratory manifestation of urological diseases, with isolated urinary syndrome and clinical and laboratory manifestation of pathology.

Results. A synchronous decrease in the metabolism of 11C-choline and 18F-FDG glucose in the kidney parenchyma and a significant increase in the bladder wall were revealed, which correlated with the severity of clinical and laboratory manifestations.

Conclusion. PET/CT technology for studying lipid and carbohydrate metabolism in the organs of the urinary system can be recommended as an additional method for diagnosing urological disorders at the early molecular-cellular stages and during navigation during targeted biopsy.

Толық мәтін

Рұқсат жабық

Авторлар туралы

B.A. Berdichevsky

FGBOU VO Tyumen State Medical University of the Ministry of Health of Russia

Хат алмасуға жауапты Автор.
Email: doktor_bba@mail.ru
ORCID iD: 0000-0002-9414-8510
SPIN-код: 4630-3855

Ph.D., MD, professor at the Department of Oncology with a course of Urology 

Ресей, Tyumen

V. Berdichevsky

FGBOU VO Tyumen State Medical University of the Ministry of Health of Russia

Email: urotgmu@mail.ru
ORCID iD: 0000-0002-0186-6514
SPIN-код: 9768-5704

Ph.D., MD, professor at the Department of Oncology with a course of Urology 

Ресей, Tyumen

E. Sapozhenkova

FGBOU VO Tyumen State Medical University of the Ministry of Health of Russia

Email: ekaterina_chibulaeva@mail.ru
ORCID iD: 0000-0003-2253-2297
SPIN-код: 7270-2232

Ph.D., associate professor at the Department of Normal Physiology 

Ресей, Tyumen

I. Pavlova

Medical Sanitary Department «Neftyanik»

Email: iraena@mail.ru

Ph.D., urologist, assistant at the Department of
Oncology with a course of Urology

Ресей, Tyumen

A. Gonyaev

Clinical Hospital «Mother and Child»

Email: a.gonyaev25@yandex.ru
ORCID iD: 0000-0002-1619-4714

urologist

Ресей, Tyumen

A. Boldyrev

GBUZ TO Regional clinical hospital No2

Email: boldyrev.a.l@yandex.ru

urologist

Ресей, Tyumen

V. Shidin

FGBOU VO Tyumen State Medical University of the Ministry of Health of Russia

Email: vshidin@mail.ru

Ph.D., MD, associate professor of the Department of Histology and Embriology

Ресей, Tyumen

N. Averina

GAUZ TO MC «Medical City»

Email: medgorod@med-to.ru

Head of the Radiological Center 

Ресей, Tyumen

A. Simonov

GAUZ TO MC "Medical City"

Email: ward72@mail.ru

Head of the Department of Oncopathology of Pathological and anatomical bureau

Ресей, Tyumen

M. Korabelnikov

GAUZ TO MC "Medical City"

Email: kma_doc@mail.ru
ORCID iD: 0000-0003-2553-0545

radiologist at the Radiological Center 

Ресей, Tyumen

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2. Fig. 1. Comparative PET/CT metabolic and morphological characteristics of the kidney parenchyma (A) and the bladder wall (B) in individuals without a urological history (on the left, molecular cellular metabolism of 11C-choline, in the middle of the kidney and bladder biopsy, on the right, 18F-FDG glucose )

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3. Fig. 2. Comparative PET/CT metabolic and morphological characteristics of the renal parenchyma (A) and the bladder wall (B) in patients with laboratory manifestations of isolated urinary syndrome and recurrent bacterial cystitis (on the left, molecular cellular metabolism of 11C-choline, in the middle, kidney and urinary biopsy bladder, right 18F-FDG glucose)

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4. Fig. 3. Comparative PET/CT metabolic and morphological characteristics of the kidney parenchyma (A) and the bladder wall (B) in patients with clinical and laboratory manifestations of a secondarily wrinkled kidney against the background of chronic pyelonephritis and late radiation cystitis (on the left, molecular cellular metabolism of 11C-choline, in the middle of the kidney and bladder biopsy, on the right 18F-FDG glucose)

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