Three-year results of the treatment of localized prostate cancer using high-intensity focused ultrasound

The study was aimed to the assessment of the effectiveness of treatment for prostate cancer using high-intensity focused ultrasound on the basis of clinical, radiation, laboratory data, and results of morphometric and immunohistochemical study of postoperative prostate biopsies. 112 sessions of HIFU-ablation of the prostate in 112 patients with localized prostate cancer were performed. Average number of impulses of action - 634+176, the average volume of tissue exposed - 34,6±15,2 cm3 per 1 session. The operative time ranged from 90 to 165 min (mean 125 min). The postoperative hospital stay ranged from 7 to 14 days (average 10±0,8 days). Intraoperative complications during HIFU-ablation were not observed. The average level of prostate-specific antigen 1,5 months after surgery was 0,7 ( 0,12-3,67 ) ng/ml. Minimum level of prostate-specific antigen was reached 20±2 weeks after treatment, and the average level was 0,26+0,01 ng/ml. 6 months after, prostate volume decreased by an average of 49%; 10-12 months after intervention, prostate volume was 6,5±2,2 cm3. Morphological analysis after treatment included studies with standard and immunohistochemical staining using the following antibodies: PCNA, Bcl2, AMACR, E-cadherin, ANDR. Recurrence-free course was observed in 96 (85,8 %) patients. Recurrences were detected in 16 (14,2%) patients, with biochemical progression in 11 (9,82 %) patients. Local recurrence (morphologically confirmed) was diagnosed in 5 (4,46 %) patients.

high-intensity focused ultrasound (HIFU), prostate cancer, immunohistochemical analysis