Experience with the use of bacteriophages in patients with neurogenic lower urinary tract dysfunction, complicated by recurrent lower urinary tract infection

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Resumo

Clinical cases of three patients with neurogenic lower urinary tract dysfunction, complicated by chronic urinary tract infection are presented in the article. All patients underwent clean intermittent catheterization and, in order to prevent symptomatic lower urinary tract infections, received bacteriophage therapy with a clinically proven positive effect. During 3 months follow-up, there were no episodes of urinary tract infection. A change in the concentration of uropathogens and restoration of sensitivity to a number of antimicrobial drugs were observed. Although phage therapy in urology requires further clinical research, it provides an additional strategy to treat urinary tract infections considering an increase in antibiotic resistance.

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Sobre autores

A. Zaitsev

FGBOU VO “Russian University of Medicine”

Autor responsável pela correspondência
Email: zaitcevandrew@mail.ru

Ph.D., MD, professor at the Department of Urology of FGBOU VO “Russian University of Medicine”

Rússia, Moscow

D. Lysachev

FGAU "Burdenko Neurosurgery Center" of the Ministry of Health of the Russia

Email: dlysachev@nsi.ru
ORCID ID: 0000-0002-9872-0959

urologist, FGAU "Burdenko Neurosurgery Center" of the Ministry of Health of the Russia

Rússia, Moscow

R. Stroganov

FGBOU VO “Russian University of Medicine”; GBU Scientific and Research Institute of the Healthcare and medical management of Moscow Health Department; S.P. Botkin’s State Clinical Hospital

Email: r.v.stroganov@gmail.com
ORCID ID: 0000-0002-5529-1787

Ph.D., assistant at the Department of Urology of FGBOU VO “Russian University of Medicine”

Rússia, Moscow; Moscow; Moscow

O. Arefieva

FGBOU VO “Russian University of Medicine”; GBU Scientific and Research Institute of the Healthcare and medical management of Moscow Health Department

Email: Oksadoc@yandex.ru
ORCID ID: 0000-0003-2309-2094

Ph.D., laboratory assistant at the Department of Urology of FGBOU VO “Russian University of Medicine”

Rússia, Moscow; Moscow

M. Dianov

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Email: dianov.mike@yandex.ru
ORCID ID: 0000-0003-1608-1688

student of N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Rússia, Moscow

E. Bryanskikh

FGBOU VO “Russian University of Medicine”

Email: lizabr@yandex.ru
ORCID ID: 0000-0002-5124-3251

student of the FGBOU VO “Russian University of Medicine”

Rússia, Moscow

A. Kovalenko

FGBOU VO Kuban State Medical University of the Ministry of Health of Russia

Email: lyaksandrakovalenko@gmail.com

student of the FGBOU VO Kuban State Medical University of the Ministry of Health of Russia

Rússia, Krasnodar

Bibliografia

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2. Fig. 1. Comprehensive urodynamic study, pressure-flow E. 54 liters. Hyposensory areflexor bladder

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3. Fig. 2. Complex urodynamic study (pressure-flow study) of patient Co., 25 years old. Normosensory bladder, no spontaneous detrusor activity is registered, bladder compliance is normal, maximum cystometric capacity is 363 ml; no detrusor contractile activity is registered in the micturition phase

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4. Fig. 3. Comprehensive urodynamic study, profilometry Co., 25 l. The urethral closure pressure is significantly elevated at 96.4 cm H2O

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