Experience with the use of bacteriophages in patients with neurogenic lower urinary tract dysfunction, complicated by recurrent lower urinary tract infection

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Clinical cases of three patients with neurogenic lower urinary tract dysfunction, complicated by chronic urinary tract infection are presented in the article. All patients underwent clean intermittent catheterization and, in order to prevent symptomatic lower urinary tract infections, received bacteriophage therapy with a clinically proven positive effect. During 3 months follow-up, there were no episodes of urinary tract infection. A change in the concentration of uropathogens and restoration of sensitivity to a number of antimicrobial drugs were observed. Although phage therapy in urology requires further clinical research, it provides an additional strategy to treat urinary tract infections considering an increase in antibiotic resistance.

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作者简介

A. Zaitsev

FGBOU VO “Russian University of Medicine”

编辑信件的主要联系方式.
Email: zaitcevandrew@mail.ru

Ph.D., MD, professor at the Department of Urology of FGBOU VO “Russian University of Medicine”

俄罗斯联邦, Moscow

D. Lysachev

FGAU "Burdenko Neurosurgery Center" of the Ministry of Health of the Russia

Email: dlysachev@nsi.ru
ORCID iD: 0000-0002-9872-0959

urologist, FGAU "Burdenko Neurosurgery Center" of the Ministry of Health of the Russia

俄罗斯联邦, Moscow

R. Stroganov

FGBOU VO “Russian University of Medicine”; GBU Scientific and Research Institute of the Healthcare and medical management of Moscow Health Department; S.P. Botkin’s State Clinical Hospital

Email: r.v.stroganov@gmail.com
ORCID iD: 0000-0002-5529-1787

Ph.D., assistant at the Department of Urology of FGBOU VO “Russian University of Medicine”

俄罗斯联邦, Moscow; Moscow; Moscow

O. Arefieva

FGBOU VO “Russian University of Medicine”; GBU Scientific and Research Institute of the Healthcare and medical management of Moscow Health Department

Email: Oksadoc@yandex.ru
ORCID iD: 0000-0003-2309-2094

Ph.D., laboratory assistant at the Department of Urology of FGBOU VO “Russian University of Medicine”

俄罗斯联邦, Moscow; Moscow

M. Dianov

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Email: dianov.mike@yandex.ru
ORCID iD: 0000-0003-1608-1688

student of N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

俄罗斯联邦, Moscow

E. Bryanskikh

FGBOU VO “Russian University of Medicine”

Email: lizabr@yandex.ru
ORCID iD: 0000-0002-5124-3251

student of the FGBOU VO “Russian University of Medicine”

俄罗斯联邦, Moscow

A. Kovalenko

FGBOU VO Kuban State Medical University of the Ministry of Health of Russia

Email: lyaksandrakovalenko@gmail.com

student of the FGBOU VO Kuban State Medical University of the Ministry of Health of Russia

俄罗斯联邦, Krasnodar

参考

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  8. Vasilyev A.O., Zaitsev A.V., Kalinina N.A., Shiriaev A.A., Kim Y.A., Pushkar D.Y. Bacteriophages in treatment of low urinary tract infections. Consilium Medicum. 2019;21(7):38–41. (In Russ.). https://doi.org/10.26442/20751753.2019.7.190511. Russian (Васильев А.О., Зайцев А.В., Калинина Н.А., Ширяев А.А., Ким Ю.А., Пушкарь Д.Ю. Бактериофаги в лечении инфекций нижних мочевыводящих путей. Consilium medicum. 2019;21(7):38–41. https://doi.org/10.26442/20751753.2019.7.190511).
  9. Shiryaev A.A., Vasiliev A.O., Zaitsev A.V., Prilepskaya E.A., Sazonova N.A., Grigoryan I.E., Kim Y.A., Pushkar D.Y. Prospect of bacteriophages application in urologic practice. Urology. 2019(6):131–136. (In Russ.). https://dx.doi.org/10.18565/urology.2019.6.131-136 Russian (Ширяев А.А., Васильев А.О., Зайцев А.В., Прилепская Е.А., Сазонова Н.А., Григорян И.Э., Ким Ю.А., Пушкарь Д.Ю. Перспектива применения бактериофагов в урологической практике. Урология. 2019(6):131–136. https://dx.doi.org/10.18565/urology.2019.6.131-136).
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2. Fig. 1. Comprehensive urodynamic study, pressure-flow E. 54 liters. Hyposensory areflexor bladder

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3. Fig. 2. Complex urodynamic study (pressure-flow study) of patient Co., 25 years old. Normosensory bladder, no spontaneous detrusor activity is registered, bladder compliance is normal, maximum cystometric capacity is 363 ml; no detrusor contractile activity is registered in the micturition phase

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4. Fig. 3. Comprehensive urodynamic study, profilometry Co., 25 l. The urethral closure pressure is significantly elevated at 96.4 cm H2O

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