Experience with the use of bacteriophages in patients with neurogenic lower urinary tract dysfunction, complicated by recurrent lower urinary tract infection
- Authors: Zaitsev A.V.1, Lysachev D.A.2, Stroganov R.V.1,3,4, Arefieva O.A.1,3, Dianov M.I.5, Bryanskikh E.P.1, Kovalenko A.A.6
-
Affiliations:
- FGBOU VO “Russian University of Medicine”
- FGAU "Burdenko Neurosurgery Center" of the Ministry of Health of the Russia
- GBU Scientific and Research Institute of the Healthcare and medical management of Moscow Health Department
- S.P. Botkin’s State Clinical Hospital
- N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia
- FGBOU VO Kuban State Medical University of the Ministry of Health of Russia
- Issue: No 1 (2024)
- Pages: 114-118
- Section: Clinical case
- URL: https://journals.eco-vector.com/1728-2985/article/view/630590
- DOI: https://doi.org/10.18565/urology.2024.1.114-118
- ID: 630590
Cite item
Open Access
Access granted
Abstract
Clinical cases of three patients with neurogenic lower urinary tract dysfunction, complicated by chronic urinary tract infection are presented in the article. All patients underwent clean intermittent catheterization and, in order to prevent symptomatic lower urinary tract infections, received bacteriophage therapy with a clinically proven positive effect. During 3 months follow-up, there were no episodes of urinary tract infection. A change in the concentration of uropathogens and restoration of sensitivity to a number of antimicrobial drugs were observed. Although phage therapy in urology requires further clinical research, it provides an additional strategy to treat urinary tract infections considering an increase in antibiotic resistance.
Full Text
About the authors
A. V. Zaitsev
FGBOU VO “Russian University of Medicine”
Author for correspondence.
Email: zaitcevandrew@mail.ru
Ph.D., MD, professor at the Department of Urology of FGBOU VO “Russian University of Medicine”
Russian Federation, MoscowD. A. Lysachev
FGAU "Burdenko Neurosurgery Center" of the Ministry of Health of the Russia
Email: dlysachev@nsi.ru
ORCID iD: 0000-0002-9872-0959
urologist, FGAU "Burdenko Neurosurgery Center" of the Ministry of Health of the Russia
Russian Federation, MoscowR. V. Stroganov
FGBOU VO “Russian University of Medicine”; GBU Scientific and Research Institute of the Healthcare and medical management of Moscow Health Department; S.P. Botkin’s State Clinical Hospital
Email: r.v.stroganov@gmail.com
ORCID iD: 0000-0002-5529-1787
Ph.D., assistant at the Department of Urology of FGBOU VO “Russian University of Medicine”
Russian Federation, Moscow; Moscow; MoscowO. A. Arefieva
FGBOU VO “Russian University of Medicine”; GBU Scientific and Research Institute of the Healthcare and medical management of Moscow Health Department
Email: Oksadoc@yandex.ru
ORCID iD: 0000-0003-2309-2094
Ph.D., laboratory assistant at the Department of Urology of FGBOU VO “Russian University of Medicine”
Russian Federation, Moscow; MoscowM. I. Dianov
N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia
Email: dianov.mike@yandex.ru
ORCID iD: 0000-0003-1608-1688
student of N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia
Russian Federation, MoscowE. P. Bryanskikh
FGBOU VO “Russian University of Medicine”
Email: lizabr@yandex.ru
ORCID iD: 0000-0002-5124-3251
student of the FGBOU VO “Russian University of Medicine”
Russian Federation, MoscowA. A. Kovalenko
FGBOU VO Kuban State Medical University of the Ministry of Health of Russia
Email: lyaksandrakovalenko@gmail.com
student of the FGBOU VO Kuban State Medical University of the Ministry of Health of Russia
Russian Federation, KrasnodarReferences
- Clinical recommendations – Chronic kidney disease (CKD) – 2021-2022-2023. Approved by the Ministry of Health of the Russian Federation; 2021. Russian (Клинические рекомендации – Хроническая болезнь почек (ХБП) - 2021-2022-2023. Утверждены Минздравом РФ; 2021).
- Engberg S., Clapper J., McNichol L., Thompson D., Welch V.W., Gray M. Current Evidence Related to Intermittent Catheterization: A Scoping Review. J Wound Ostomy Continence Nurs. 2020;47(2):140–165. https://doi.org/10.1097/won.0000000000000625
- Harper D.R., Parracho H.M.R.T., Walker J., Sharp R., Hughes G., Werthén M., Lehman S., Morales S. Bacteriophages and Biofilms. Antibiotics. 2014;3(3):270–284. https://doi.org/10.3390/antibiotics3030270
- Leitner L., Kessler T.M., Klumpp J. Bacteriophages: a Panacea in Neuro-Urology? Eur Urol Focus. 2020;6(3):518–521. https://doi.org/10/1016/j.euf.2019.10.018
- Lahno V.M. Primenenie polivalentnogo piobakteriofaga dlya profilaktiki oslozhnenij pri aktivnom hirurgicheskom lechenii gnojnyh ran. Aktual’nye voprosy hirurgii. 1996:267–269. Russian (Лахно В.М. Применение поливалентного пиобактериофага для профилактики осложнений при активном хирургическом лечении гнойных ран. Актуальные вопросы хирургии. 1996:267–269).
- Kisina V.I. Perepanova T.S., Zabirov K.I., Bednova V.N., Vasiliev M.M., Darbeeva O.S., Danilova T.N. Phage therapy of inflammatory urogenital diseases in women. Vestnik dermatologii i venerologii. 1996;5:45–48. Russian (Кисина В.И., Перепанова Т.С., Забиров К.И., Беднова В.Н., Васильев М.М., Дарбеева О.С., Данилова Т.М. Фаготерапия воспалительных урогенитальных заболеваний у женщин. Вестник дерматологии и венерологии. 1996;5:45–48).
- Perepanova T.S., Darbeeva O.S., Kotliarova G.A., Kondrat’eva E.M., Maĭskaia L.M., Malysheva V.F., Baĭguzina F.A., Grishkova N.V. The efficacy of bacteriophage preparations in treating inflammatory urologic diseases. Urol Nefrol. 1995:(5):14–17. Russian (Перепанова Т.С., Дарбеева О.С., Котлярова Г.А., Кондратьева Е.М., Майская Л.М., Малышева В.Ф., Байгузина Ф.А., Гришкова Н.В. Эффективность препаратов бактериофагов при лечении воспалительных урологических заболеваний. Урология и нефрология. 1995;5:14–17).
- Vasilyev A.O., Zaitsev A.V., Kalinina N.A., Shiriaev A.A., Kim Y.A., Pushkar D.Y. Bacteriophages in treatment of low urinary tract infections. Consilium Medicum. 2019;21(7):38–41. (In Russ.). https://doi.org/10.26442/20751753.2019.7.190511. Russian (Васильев А.О., Зайцев А.В., Калинина Н.А., Ширяев А.А., Ким Ю.А., Пушкарь Д.Ю. Бактериофаги в лечении инфекций нижних мочевыводящих путей. Consilium medicum. 2019;21(7):38–41. https://doi.org/10.26442/20751753.2019.7.190511).
- Shiryaev A.A., Vasiliev A.O., Zaitsev A.V., Prilepskaya E.A., Sazonova N.A., Grigoryan I.E., Kim Y.A., Pushkar D.Y. Prospect of bacteriophages application in urologic practice. Urology. 2019(6):131–136. (In Russ.). https://dx.doi.org/10.18565/urology.2019.6.131-136 Russian (Ширяев А.А., Васильев А.О., Зайцев А.В., Прилепская Е.А., Сазонова Н.А., Григорян И.Э., Ким Ю.А., Пушкарь Д.Ю. Перспектива применения бактериофагов в урологической практике. Урология. 2019(6):131–136. https://dx.doi.org/10.18565/urology.2019.6.131-136).
- Zaitsev A.V., Vasiliev A.O., Shiryaev A.A., Arefieva O.A., Pushkar D.Y. Search for new solutions in the prevention of catheter-associated infection in urology. Works of the Research Institute of Health Care Organization and Medical Management 2021. pp. 164–167. Russian (Зайцев А.В., Васильев А.О., Ширяев А.А., Арефьева О.А., Пушкарь Д.Ю. Поиск новых решений в профилактике развития катетер-ассоциированной инфекции в урологии. Труды Научно-исследовательского института организации здравоохранения и медицинского менеджмента 2021. pp. 164–167).
Supplementary files
