The role of ACE gene polymorphism in development of erectile dysfunction in patients with metabolic syndrome
- 作者: Gamidov SI1, Iremashvili VV1, Nosikov VV1, Gamidov SI1, Iremashvili VV1, Nosikov VV1
-
隶属关系:
- 期: 编号 1 (2011)
- 页面: 34-37
- 栏目: Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/279012
- ID: 279012
如何引用文章
全文:
详细
To ascertain relations between angiotensin converting enzyme (ACE) gene polymorphism and erectile dysfunction (ED) in male citizens of Russia with metabolic syndrome, we made a retrospective comparative analysis of ACE gene polymorphism incidence rate in two groups of males with metabolic syndrome: with ED (n = 385) and free of ED (n = 152). We discovered that ED patients have DD genotype and D-allele more frequently (68.3 vs 38.2%, p < 0.001 and 81.3 vs 63.8%, p < 0.001, respectively). Moreover, severe ED is associated with significantly more frequent incidence of genotype DD compared to moderate and mild ED. Incidence of allele D is also more frequent in patients with severe ED (93.4%). Thus, D-allele of ACE gene is an ED risk factor in males with metabolic syndrome. Therefore, ED can be considered as one of vascular complications of metabolic syndrome.
参考
- Eckel R. H., Grundy S. M., Zimmet P. Z. The metabolic syndrome. Lancet 2005; 365: 1415-1428.
- Reaven G. M. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-1607.
- Esposito K., Giugliano F., Martedi E. et al. High proportions of erectile dysfunction in men with the metabolic syndrome. Diabet. Care 2005; 28: 1201-1203.
- Kifor I., Williams G. H., Vickers M. A. et al. Tissue angiotensin II as a modulator of erectile function. I. Angiotensin peptide content, secretion and effects in the corpus cavernosum. J. Urol. (Baltimore) 1997; 157: 1920-1925.
- Rigat B., Hubert C., Alhenc-Gelas F. et al. An insertion/deletion polymorphism in the angiotensin 1-converting enzyme gene accounting for half the variance of serum enzyme levels. J. Clin. Invest. 1990; 86: 1343-1346.
- Montgomery H., Humphries S., Danilov S. Is genotype or phenotype the better tool for investigating the role of ACE in human cardiovascular disease? Eur. Heart J. 2002; 23: 1083-1086.
- Mattu R. K., Needham E. W. A., Galton D. J. et al. A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly Heart Study. Circulation 1995; 91: 270-274.
- Park J. K., Kim W., Kim S. W. et al. Gene-polymorphisms of angiotensin converting enzyme and endothelial nitric oxide synthase in patients with erectile dysfunction. Int. J. Impot. Res. 1999; 11: 273-276.
- Rosas-Vargas H., Coral-Vazquez R. M., Tapia R. et al. Glu298Asp endothelial nitric oxide synthase polymorphism is a risk factor for erectile dysfunction in the Mexican Mestizo population. J. Androl. 2004; 25: 728-732.
- Ferrario C. M. Role of angiotensin II in cardiovascular disease therapeutic implications of more than a century of research. J. Renin Angiotensin Aldosterone Syst. 2006; 7: 3-14.
补充文件
![](/img/style/loading.gif)