The role of ACE gene polymorphism in development of erectile dysfunction in patients with metabolic syndrome


Cite item

Full Text

Abstract

To ascertain relations between angiotensin converting enzyme (ACE) gene polymorphism and erectile dysfunction (ED) in male citizens of Russia with metabolic syndrome, we made a retrospective comparative analysis of ACE gene polymorphism incidence rate in two groups of males with metabolic syndrome: with ED (n = 385) and free of ED (n = 152). We discovered that ED patients have DD genotype and D-allele more frequently (68.3 vs 38.2%, p < 0.001 and 81.3 vs 63.8%, p < 0.001, respectively). Moreover, severe ED is associated with significantly more frequent incidence of genotype DD compared to moderate and mild ED. Incidence of allele D is also more frequent in patients with severe ED (93.4%). Thus, D-allele of ACE gene is an ED risk factor in males with metabolic syndrome. Therefore, ED can be considered as one of vascular complications of metabolic syndrome.

References

  1. Eckel R. H., Grundy S. M., Zimmet P. Z. The metabolic syndrome. Lancet 2005; 365: 1415-1428.
  2. Reaven G. M. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-1607.
  3. Esposito K., Giugliano F., Martedi E. et al. High proportions of erectile dysfunction in men with the metabolic syndrome. Diabet. Care 2005; 28: 1201-1203.
  4. Kifor I., Williams G. H., Vickers M. A. et al. Tissue angiotensin II as a modulator of erectile function. I. Angiotensin peptide content, secretion and effects in the corpus cavernosum. J. Urol. (Baltimore) 1997; 157: 1920-1925.
  5. Rigat B., Hubert C., Alhenc-Gelas F. et al. An insertion/deletion polymorphism in the angiotensin 1-converting enzyme gene accounting for half the variance of serum enzyme levels. J. Clin. Invest. 1990; 86: 1343-1346.
  6. Montgomery H., Humphries S., Danilov S. Is genotype or phenotype the better tool for investigating the role of ACE in human cardiovascular disease? Eur. Heart J. 2002; 23: 1083-1086.
  7. Mattu R. K., Needham E. W. A., Galton D. J. et al. A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly Heart Study. Circulation 1995; 91: 270-274.
  8. Park J. K., Kim W., Kim S. W. et al. Gene-polymorphisms of angiotensin converting enzyme and endothelial nitric oxide synthase in patients with erectile dysfunction. Int. J. Impot. Res. 1999; 11: 273-276.
  9. Rosas-Vargas H., Coral-Vazquez R. M., Tapia R. et al. Glu298Asp endothelial nitric oxide synthase polymorphism is a risk factor for erectile dysfunction in the Mexican Mestizo population. J. Androl. 2004; 25: 728-732.
  10. Ferrario C. M. Role of angiotensin II in cardiovascular disease therapeutic implications of more than a century of research. J. Renin Angiotensin Aldosterone Syst. 2006; 7: 3-14.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2011 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies