Imidafenacin for treatment of overactive bladder and urgent urinary incontinence: the results of open-label multicenter randomized controlled clinical trial
- 作者: Al-Shukri S.H1, Pushkar D.Y.2, Apolikhin O.I3, Evdokimov M.S4, Kogan M.I5, Krivoborodov G.G6, Kagan O.F7, Petrov S.B8, Poltoratskyi A.N9, Kuzmin I.V1, Sharvadze G.G10
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隶属关系:
- FGBOU VO «Pavlov First Saint Petersburg State Medical University» of Minzdrav of Russia
- A.I. Evdokimov Moscow State University of Medicine and Dentistry of Minzdrav of Russia
- FGBU «The National Medical Research Radiologic Center» of Minzdrav of Russia
- Family Policlinic №4 LLC
- FGBOU VO Rostov State Medical University of Minzdrav of Russia
- N.I. Pirogov RNRMU of Minzdrav of Russia
- Hospital Orkli LTD
- FGBU «All-Russian Centre of Emergency and Radiation Medicine named after A.M. Nikiforov» of the Emergency of Russia
- Baltic Medicine LTD ООО
- AO «R-Farm»
- 期: 编号 6 (2018)
- 页面: 20-25
- 栏目: Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/296418
- DOI: https://doi.org/10.18565/urology.2018.6.20-25
- ID: 296418
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作者简介
S. Al-Shukri
FGBOU VO «Pavlov First Saint Petersburg State Medical University» of Minzdrav of Russia
Email: alshukri@mail.ru
Dr.Med.Sci., professor, Head of the Department of Urology
D. Pushkar
A.I. Evdokimov Moscow State University of Medicine and Dentistry of Minzdrav of Russia
Email: pushkardm@mail.ru
corresponding member of RAS, Dr.Med.Sci., professor, Head of the Department of Urology
O. Apolikhin
FGBU «The National Medical Research Radiologic Center» of Minzdrav of Russia
Email: apolikhin.oleg@gmail.com
corresponding member of RAS, Dr.Med.Sci., professor, Director
M. Evdokimov
Family Policlinic №4 LLC
Email: 6733146@mail.ru
Cand.Med.Sci., urologist
M. Kogan
FGBOU VO Rostov State Medical University of Minzdrav of Russia
Email: dept_kogan@mail.ru
Dr.Med.Sci., professor, Head of the Department of urology and reproductive health with the course of pediatric urology and andrology
G. Krivoborodov
N.I. Pirogov RNRMU of Minzdrav of Russia
Email: dr.krivoborodov@yandex.ru
Dr.Med.Sci., professor at the Department ofUrology and Andrology
O. Kagan
Hospital Orkli LTD
Email: ofkagan@mail.ru
Dr.Med.Sci., Professor, Head of the Department of Urology
S. Petrov
FGBU «All-Russian Centre of Emergency and Radiation Medicine named after A.M. Nikiforov» of the Emergency of Russia
Email: petrov-uro@yandex.ru
Dr.Med.Sci., Professor, Head of the Department of Urology
A. Poltoratskyi
Baltic Medicine LTD ООО
Email: 1.5artem@gmail.com
urologist
I. Kuzmin
FGBOU VO «Pavlov First Saint Petersburg State Medical University» of Minzdrav of Russia
Email: kuzminigor@mail.ru
Dr.Med.Sci., Professor at the Department of Urology
G. Sharvadze
AO «R-Farm»
Email: sharvadze@rpharm.ru
Ph.D., medical advisor of the Group of Medical support of the business in CIS countries /RF
参考
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- Vouri S.M., Kebodeaux C.D., Stranges P.M., Teshome B.F. Adverse events and treatment discontinuations of antimuscarinics for the treatment of overactive bladder in older adults: A systematic review and meta-analysis. Arch Gerontol Geriatr. 2017;69:77-96. doi: 10.1016/j.archger.2016.11.006.
- Kobayashi F., Yageta Y., Segawa M., Matsuzawa S. Effects of imidafenacin (KRP-197/ONO-8025), a new anti-cholinergic agent, on muscarinic acetylcholine receptors. High affinities for M3 and M1 receptor subtypes and selectivity for urinary bladder over salivary gland. Arzneimittelforschung. 2007; 57(2): 92-100. doi: 10.1055/s-0031-1296589.
- Ohmori S., Miura M., Toriumi C. et al. Absorption, metabolism, and excretion of imidafenacin, a new compound for treatment of overactive bladder, after oral administration to healthy male subjects. Drug Metab Dispos. 2007;35(9):1624-1633. doi: 10.1124/dmd.107.016030.
- Aizawa N., Ito H., Sugiyama R. et al. Selective inhibitory effect of imidafenacin and 5-hydroxymethyl tolterodine on capsaicin sensitive C. fibers of the primary bladder mechanosensitive afferent nerves in the rat. J. Urol. 2015;193(4):1423-1432. doi: 10.1016/j.juro.2014.09.005.
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- Yokoyama T., Koide T., Hara R. et al. Long-term safety and efficacy of two different antimuscarinics, imidafenacin and solifenacin, for treatment of overactive bladder: a prospective randomized controlled study. Urol Int. 2013;90(2):161-167. doi: 10.1159/000345055.
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补充文件
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