Features of the Spectral Surface Estimation of Titanium Implants for Animals

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Abstract

The paper presents the study results relating to the material state of the implants made of titanium alloy and coated with chitosan. The implants have been studied before and after preclinical use in animals. A feature of this research method is the use of Raman scattering spectroscopy with a high sensitivity in the region of 400–1 800 cm−1. Confirmation of the implant surface study results was obtained using the scanning electron microscopy. The details of spectral changes are taken as an indirect estimate of the complete biodegradation of the implant coating after one month.

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About the authors

P. E. Timchenko

Korolev Samara National Research University

Author for correspondence.
Email: journal@electronics.ru
Russian Federation, Samara

E. V. Timchenko

Korolev Samara National Research University

Email: journal@electronics.ru
Russian Federation, Samara

D. A. Dolgushkin

Samara State Medical University, Institute of Experimental Medicine and Biotechnology

Email: journal@electronics.ru
Russian Federation, Samara

O. O. Frolov

Korolev Samara National Research University

Email: journal@electronics.ru
Russian Federation, Samara

A. N. Nikolaenko

Samara State Medical University, Institute of Experimental Medicine and Biotechnology

Email: journal@electronics.ru
Russian Federation, Samara

L. T. Volova

Samara State Medical University, Institute of Experimental Medicine and Biotechnology

Email: journal@electronics.ru
Russian Federation, Samara

A. Yu. Ionov

Korolev Samara National Research University

Email: journal@electronics.ru
Russian Federation, Samara

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Supplementary files

Supplementary Files
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2. Fig. 1. Samples of VT6 titanium in the form of bars with the chitosan-based coating in a sterile package.

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3. Fig. 2. Sample implantation of the rat scapula

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4. Fig.3. Scanning electron microscopy of a VT6 titanium chitosan-coated sample, magnification 30

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5. Fig.4. Scanning electron microscopy of a VT6 titanium chitosan-coated sample, magnification 1000. Inhomogeneous coating areas have a smooth and uneven relief

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6. Fig. 5. Scanning electron microscopy of a VT6 titanium chitosan-coated sample, magnification 2000: a - area with uneven relief; b - area covered with a transparent film

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7. Fig.6. Scanning electron microscopy of a VT6 titanium chitosan-coated sample, magnification 1 000. Peeling of a film coating area

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8. Fig. 7. Normalized Raman spectra of the studied VT6 titanium chitosan-coated samples: 1 – before implantation, 2 – 1 week after implantation, 3 – 1 month after the animal withdrawal from the experiment

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9. Fig. 8. Calculation results: a) Linear discriminant function graph: 1 – before implantation, 2 – 1 week after implantation, 3 – 1 month after the animal withdrawal from the experiment; b) Factor structure coefficient values

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Copyright (c) 2023 Timchenko P.E., Timchenko E.V., Dolgushkin D.A., Frolov O.O., Nikolaenko A.N., Volova L.T., Ionov A.Y.

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