Experimental model of Helicobacter-like of gasticmucosal injury
- 作者: Spasov AA1, Chernikov MV1, Speranskaya AS1, Zaychenko SI1, Spasov AA1, Chernikov MV1, Speranskaya AS1, Zaichenko SI1
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隶属关系:
- 期: 卷 2, 编号 3 (2005)
- 页面: 24-26
- 栏目: Articles
- URL: https://journals.eco-vector.com/1994-9480/article/view/139968
- ID: 139968
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The present study was designed to examine the role of ammonia-monochloramine system in gastic mucosal injury.
Mucosal application of ammonia in sub erosive concentration (100 mM) leads to insignificant lesions in unanesthetized
rat stomach. Mucosal exposure to ammonia (100 mM) plus acute ischemia by bleeding from the carotid artery followed
monochloramine synthesis caused severe hemorrhagic gastric lesions. These results suggest that monochloramine
damages the gastric mucosa at much lower concentration than ammonia and this testing procedure may be used as a
model of Helicobacter pylori-associated injury of gastric mucous.
Mucosal application of ammonia in sub erosive concentration (100 mM) leads to insignificant lesions in unanesthetized
rat stomach. Mucosal exposure to ammonia (100 mM) plus acute ischemia by bleeding from the carotid artery followed
monochloramine synthesis caused severe hemorrhagic gastric lesions. These results suggest that monochloramine
damages the gastric mucosa at much lower concentration than ammonia and this testing procedure may be used as a
model of Helicobacter pylori-associated injury of gastric mucous.
参考
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