Safety of OTC-drugs in pregnancy


Cite item

Full Text

Abstract

The use of OTC drugs during pregnancy can lead to serious health consequences for mother and fetus/newborn. We analyze the safety of medicines most frequently used during pregnancy. Doctors must take measures to educational work with pregnant women and control of all drugs use, including herbal drugs and dietary supplements for a period of gestation.

References

  1. Wilson JG. Current status of teratology. In: Wilson JG, Fraser FC, eds. Handbook of teratology. New York: Plenum 1977:47.
  2. Kacew S. Effects of over-the-counter drugs on the unborn child: what is known and how should this influence prescribing? Paediatr Drugs 1999;1(2):75-80.
  3. Splinter MY, Sagraves R, Nightengale B, et al. Prenatal use of medications by women giving birth at a university hospital. South Med J 1997;90:498-502.
  4. Anonymous. OTC Drugs Can Be Harmful to the Unborn Child. Drug Ther Perspect 2000;16(3):12-14.
  5. Shaheen SO, Newson RB, Sherriff A, et al. Paracetamol use in pregnancy and wheezing in early childhood. Thorax 2002;57(11):958-63.
  6. Gill EJ, Contos MJ, Peng TC. Acute fatty liver of pregnancy and acetaminophen toxicity leading to liver failure and postpartum liver transplantation. A case report. J Reprod Med 2002;47(7):584-86.
  7. Black RA, AshleyH. Over-the-Counter Medications in Pregnancy. Am Fam Physician 2003;67:2517-24.
  8. Kozer E, Costei AM, Boskovic R, et al. Effects of aspirin consumption during pregnancy on pregnancy outcomes: meta-analysis. Birth Defects Res B Dev Reprod Toxicol 2003;68(1):70-84.
  9. Hauth JC, Goldenberg RL, Parker CR, et al. Low-dose aspirin: lack of association with an increase in abruptio placentae or perinatal mortality. Obstet Gynecol 1995;85:1055-58.
  10. Kacew S. Drugs in gastrointestinal disorders in developing infants. In: Kacew S, editor. Drug toxicity and metabolism in pediatrics. Boca Raton: CRC Press 1990:265-94.
  11. Kargas GA, Kargas SA, Bruyere HJ, et al. Perinatal mortality due to interaction of diphenhydramine and temazepam. N Engl J Med 1985;313:1417-18.
  12. Blaiss MS; Food and Drug Administration (U.S.); ACAAI-ACOG(American College of Allergy, Asthma, and Immunology and American College of Obstetricians and Gynecologists.). Management of rhinitis and asthma in pregnancy. Ann Allergy Asthma Immunol 2003;90(6 Suppl. 3):16-22.
  13. Einarson A, Lyszkiewicz D, Koren G. The safety of dextromethorphan in pregnancy: results of a controlled study. Chest 2001;119:466-69.
  14. Aselton P, Jick H, Milunsky A, et al. First-trimester drug use and congenital disorders. Obstet Gynecol 1985;65:451-55.
  15. Shaw GM, Todoroff K, Velie EM, et al. Maternal illness, including fever and medication use as risk factors for neural tube defects. Teratology 1998;57:1-7.
  16. Robertson WC. Calcium carbonate consumption during pregnancy: an unusual cause of neonatal hypocalcemia. J Child Neurol 2002;17(11):853-55.
  17. Parker S, Udani M, Gavaler JS, et al. Pre- and neonatal exposure to cimetidine but not ranitidine adversely affects adult sexual functioning of male rats. Neurobehav Toxicol Teratol 1984;6(4):313-18.
  18. Takeshi S, Kai H, Suita S. Effects of the prenatal administration of cimetidine on testicular descent and genital differentiation in rats. Surgery 2002;131(1 Suppl.):S301-305.
  19. King CT, Rogers PD, Cleary JD, et al. Antifungal therapy during pregnancy. Clin Infect Dis 1998;27:1151-60.
  20. Czeizel AE, Toth M, Rockenbauer M. No teratogenic effect after clotrimazole therapy during pregnancy. Epidemiology 1999;10:437-40.
  21. Koren G, Dugoua JJ, Magee L, et al. MotherNature: establishing a Canadian research network for natural health products (NHPs) during pregnancy and lactation. J Altern Complement Med 2008;14(4):369-72.
  22. Dugoua JJ, Mills E, Perri D, et al. Safety and efficacy of ginkgo (Ginkgo biloba) during pregnancy and lactation. Can J Clin Pharmacol 2006Fall;13(3):e277-84.
  23. Dugoua JJ, Mills E, Perri D, et al. Safety and efficacy of St. John's wort (hypericum) during pregnancy and lactation. Can J Clin Pharmacol 2006 Fall;13(3):e268-76.
  24. Perri D, Dugoua JJ, Mills E, et al. Safety and efficacy of echinacea (Echinacea angustafolia, e. purpurea and e. pallida) during pregnancy and lactation. Can J Clin Pharmacol 2006 Fall;13(3):e262-67.
  25. Holst L, Nordeng H, Haavik S. Use of herbal drugs during early pregnancy in relation to maternal characteristics and pregnancy outcome. Pharmacoepidemiol Drug Saf 2008;17(2):151-59.
  26. Petty H, Fernando M, Kindzelskii A, et al. Identification of colchicine in placental blood from patients using her-bal medicines. Chemical Research Toxicology 2001;14(9):1254-58.
  27. Chuang CH, Doyle P, Wang JD, et al. Herbal medicines used during the first trimester and major congenital malformations: an analysis of data from a pregnancy cohort study. Drug Saf 2006;29(6):537-48.
  28. Ab Rahman A, Ahmad Z, Naing L, et al. The use of herbal medicines during pregnancy and perinatal mortality in Tumpat District, Kelantan, Malaysia. Southeast Asian J Trop Med Public Health 2007;38(6):1150-57.
  29. Hulisz DT. Top Herbal Products: Efficacy and Safety Concerns. Release Date: January 4, 2008; http://www.medscape.com/viewprogram/8494_pnt.
  30. http://www.pharmateca.ru/cgi-bin/statyi.pl?sid=2191&mid=1085056555&magid=164

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies