No 1 (2009)

The problem of cardiovascular disease (CVD) in postmenopausal women is discussed. We consider the pathogenesis of CVD secondary to the decrease of content of sex hormones in this period, as well as the prevention and correction of these disturbances. We emphasize the role of hormone replacement therapy and particularities of its effective application, the significance of use of psychotropics, antidepressants especially, and antihypertensive drugs (ACE inhibitors, beta-adrenergic blockers, thiazide diuretics). Physicians must take into account the existing functional and organic changes that occur in a woman's body in perimenopausal period as well as the full range of therapeutic effects of drugs in choice of therapeutic and preventive measures

Creation of the concept of specialized medical care becomes more urgent due to the high incidence of HIV (human immunodeficiency virus) in the world, including Russia, and increase of number of people infected with HIV through heterosexual sex intercourses, including women of any reproductive age, including adolescents. The issues related to reproductive health and fertility regulation in HIV-infected wedded pairs and options for assistance in various clinical situations are discussed.

Varicose veins and telangiectasia are the most common manifestations of chronic venous disorders of lower limbs (HVD). The presence of trophic disturbances on the low limb skin is associated with decompensation of chronic venous disease and characterizes the development of chronic venous insufficiency (CVI). High incidence of this pathology; illness; severe complications - all of these require careful and competent treatment of varicose veins in the lower limbs by any medical practitioner. The possibilities of general practitioner in terms of diagnosis and treatment HVD and CVI are discussed. The present classification CEAR identified optimal levels of diagnosis for each class of diseases - from zero to six (the last). It is emphasized that existing therapeutic and diagnostic phlebological methods aimed to improvement of patients quality of life, and treatment programs depends not only on the characteristics of the venous system lesions and the clinical class of disease, but also on the expectations of each patient.

Programmed delivery in women with high perinatal risk is reliable way to reduce the risk of perinatal complications. However, the unwillingness of the cervix is a major predictor of future anomalies of uterine activity. It can be overcome in various ways, but in comparison with known methods (the introduction of laminaria sticks, the use of prostaglandin gel) Mifepristone administration is the most effective. Lack of effect of Mifepristone administration should be considered as an additional risk factor for adverse pregnancy and delivery outcomes. In this connection it is necessary to promptly resolve the issue of abdominal delivery.

The results of the examination of 62 patients with cystic fibrosis (CF) aged from one month to 29 years living in the Udmurt Republic (UR) are presented. We analyzed the prevalence, population frequency, epidemiological and genetic characteristics of the disease. The frequency of dominant mutations in the UR delF508 mutation is 37.1%, unidentified mutations are more common in patients of Finno-Ugric ethnic group. Some aspects of modern therapy of disease are discussed.