ANTIANGIOGENNYE PREPARATY V LEChENII RAKA MOLOChNOY ZhELEZY


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Abstract

Рассматривается значение ангиогенеза в прогрессировании и дальнейшем метастазировании опухоли. Подчеркивается, что ангиогенез является привлекательной мишенью для целенаправленной ("таргетной") противоопухолевой терапии. Можно рассчитывать, что при раке молочной железы и других злокачественных опухолях проведение антиангиогенной терапии станет наиболее эффективным видом адъювантного лечения на ранних этапах развития метастазов и до васкуляризации опухоли. Представлены результаты клинических исследований, подтверждающих эффективность бевацизумаба, блокирующего рецепторное связывание VEGF (наиболее мощного стимулятора ангиогенеза), у больных метастатическим раком молочной железы.

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