DINAMIKI KONTsENTRATsII MAGNIYa V KROVI POSLE PRIEMA RAZLIChNYKh MAGNESODERZhAShchIKh PREPARATOV

Abstract

The results of a comparative study evaluated the intake of Magne B6 various forms (solution for drinking and tablets), which contains an organic salt of magnesium, and Berokka Plus, which contains inorganic salt of magnesium in 16 volunteers are presented. These data suggest that the Magne B6 statistically significantly raises levels of magnesium in plasma and erythrocytes, while the comparison drug are not lead to statistically significant differences in magnesium levels before and after use. Drug absorption dynamics in the intestine of various forms Magne B6 are different. Thus, liquid form of Magne B6 more effectively raises the levels of magnesium in plasma compared with the control within 2-3 hours. At the same time, Magne B6 in tablets contribute to a more prolonged retention of high concentrations of magnesium in red blood cells within 6-8 hours.

References

  1. Громова О.А. Магний и пиридоксин: основы знаний. М., 2006. С. 176.
  2. Durlach J, Pages N, Bac P, et al. Magnesium depletion with hypo- or hyperfunction of the biological clock may be involved in chronopathological forms of asthma. Magnes Res 2005;18(1):19-34.
  3. Durlach J, Pages N, Bac P, et al. Chronopathological forms of magnesium depletion with hypofunction or with hyperfunction of the biological clock. Magnes Res 2002;15(34):263-68.
  4. Saris NEL, Mervaala E, Karppanen H, et al. Magnesium. An update on physiological, clinical and analytical aspects. Clin Chim Acta 2000;249:1-26.
  5. Ranade VV, Somberg JC. Bioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans. Am J Ther 2001;8(5):345-57.
  6. Holtmeier HJ. Magnesium deficiency syndrome. Z Allgemeinmed 1972;48(4):152-59.
  7. Classen HG, Classen UG, Grimm P, et al. Pharmacokinetics of magnesium salts. Methods Find Exp Clin Pharmacol 1992;14(4):261-68.
  8. Li XC, Yu C, Sun WK, et al. Pharmacokinetics of magnesium lithospermate B after intravenous administration in beagle dogs. Acta Pharmacol Sin 2004;25(11):1402-07.
  9. Hu Q, Ding J, Liu S, et al. Pharmacokinetics of magnesium glycyrrhizinate following intravenous administration of magnesium glycyrrhizinate in rats. Eur J Drug Metab Pharmacokinet 2003;28(4):259-64.
  10. Aideloje SO, Onyeji CO, Ugwu NC. Altered pharmacokinetics of halofantrine by an antacid, magnesium carbonate. Eur J Pharm Biopharm 1998;46(3):299-303.
  11. Martin PD, Schneck DW, Dane AL, Warwick MJ.The effect of a combination antacid preparation containing aluminium hydroxide and magnesium hydroxide on rosuvastatin pharmacokinetics. Curr Med Res Opin. 2008;24(4):1231-35.
  12. Дорохов В.В., Холодов Л.Е. Программа ASKID для фармакокинетических расчетов. 1995.
  13. Конюхова О.С., Ших Е.В., Красных Л.М. Результаты применения магнийсодержащих препаратов и различных нагрузочных доз витаминов В1 и В2 у добровольцев // Вопросы питания. 2006. № 6. С. 24-29.
  14. Мартынов А.И., Остроумова О.Д., Мамаев В.И. и др. Роль магния в патогенезе и лечении артериальной гипертонии // Терапевтический архив. 1999. № 12. С. 67-69.
  15. Регистр лекарственных средств России (РЛС). Энциклопедия лекарств. 16 й выпуск. М. 2007. С. 1456.
  16. Bolan JC, Craft JB, Patch JH, et al. Pharmacokinetics of magnesium sulfate in the sheep model. Pediatr Pharmacol 1985;5(3):189-99.
  17. Chuan FS, Charles BG, Boyle RK, et al. Population pharmacokinetics of magnesium in preeclampsia. Am J Obstet Gynecol 2001;185(3):593-99.
  18. Ebel H, Classen HG, Marquardt P, et al. Pharmacology and pharmacokinetics of magnesium. MMW 1975;117(29-30):1243-48.
  19. Ryszka F, Dolinski W, Krupej J. Bioavailability and pharmacokinetics of magnesium after magnesium fumarate administration in humans.Boll. Chim Farm 1997;136(9):575-76.
  20. Kanabrocki EL, Sothern RB, Ryan MD, et al. Circadian characteristics of serum calcium, magnesium and eight trace elements and of their metallo-moieties in urine of healthy middle-aged men. Clin Ter 2008;159(5):329-46.

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