Portal vein thrombosis in the practice of gastroenterologist


Cite item

Full Text

Abstract

Portal vein thrombosis (PVT) is the process of thrombus formation up to complete occlusion of the lumen of the main trunk and branches of PV with progressive disorder of blood flow in the liver and gastrointestinal tract. The data for the portal vein system, the etiology and pathogenesis of PVT are presented. We consider the clinical picture of PVT, the principles of its diagnosis and treatment. It is emphasized that PVT is a serious disease requiring immediate diagnosis and intensive treatment to prevent complications, such as the formation of cavernous transformation and progression of portal hypertension. We discuss the clinical case of PTV in a patient with primary polycythemia.

References

  1. Пономарев А.А. Изолированный тромбоз мезентериальных ветвей воротной вены // РМЖ. 1992. № 5 (12). С. 27-29.
  2. Жестовская С.И., Гракова Л.С., Аксенова Н.А. Клиническое примение дуплексного сканирования в выявлении коллатерального кровообращения при портальной гипертензии // Первая краевая. 2001. № 10. С. 10-12.
  3. Шерлок Ш., Дули Дж. Заболевание печени и желчных путей М.: ГЭОТАР, 1999. С. 184-85.
  4. Митьков В.В. Допплерография в диагностике заболеваний печени, желчного пузыря, поджелудочной железы и их сосудов. М: ВИДАР, 2000. 152 с.
  5. Valla D, Casadevall N, Huisse MG, et al. Etiology of portal vein thrombosis in adults. A prospective evaluation of primary myeloproliferative disorders. Gastroenterology 1988;94:1063-69.
  6. Webb LJ, Sherlock S. The aetiology, presentation and natural history of extrahepatic portal venous obstruction. Q J Med 2002;192:627-39.
  7. Rosendaal FR. Venous thrombosis: a multicausal disease. Lancet 1999;353:1167-73.
  8. Denninger MH, Chait Y, Casadevall N, et al. Cause of portal or hepatic venous thrombosis in adults: the role of multiple concurrent factors. Hepatology 2000;31:587-91.
  9. A Janssen HL, Wijnhoud A, Haagsma EB, et al. Extrahepatic portal vein thrombosis: aetiology and determinants of survival Gut 2001;49:720-24.
  10. Valla D, Condat B. Portal vein thrombosis in adults: pathophysiology, pathogenesis and management. J Hepatol 2000;32:865-71.
  11. Bertina RM, Koeleman RPC, Koster T, et al. Mutation in blood coagulation factor V assotiated with resistance to activated protein C. Nature 1994;369:64-7.
  12. Cohen J, Edelman RR, Chopra S. Portal vein thrombosis. A review. Am J Med 1992;92:173-82.
  13. Janssen HLA, Meinardi JR, Vleggaar FP, et al. Factor V Leiden mutation, prothrombin gene mutation and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis. Results from a collaborative case-control study. Blood 2000;96:2364-68.
  14. Cardin F, Graffeo M, McCormick PA, et al. Adult "idiopathic" extrahepatic venous thrombosis. Importance of putative "latent" myeloloproliferative disorders and comparison with cases with known etiology. Dig Dis Sci 1992;37:335-39.
  15. Abhasnee Sobhonslidsuk K. Rajender Reddy. Portal vein thrombosis: A Concise Review Am J Med 2002; 97:535-41.
  16. Vandenbroucke JP, Koster T, Briеt E, et al. Increased risk of venous thrombosis in oral contraceptive users who are carriers of factor V Leiden mutation. Lancet 1994;344:1453-57.
  17. Janssen HLA, Meinardi JR, Vleggaar FP, et al. Factor V Leiden mutation, prothrombin gene mutation and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis. Results from a collaborative case-control study. Blood 2000;96:2364-68.
  18. Mahmoud AEA, Elias E, Beaucgamp N, et al. Prevalence of the factor V Leiden mutation in hepatic and portal vein thrombosis. Gut 1997;40:798-800.
  19. Ueno N, Sasaki A, Tomiyama T, et al. Color doppler ultrasonography in the diagnosis of cavernous transformation of the portal vein. J Clin Ultrasound 1997;25:221-33.
  20. Condat B, Valla D, Erlinger S. Acute portal vein thrombosis: characteristics and outcome. Hepatology 1998;28:455A.
  21. Galloway JR, Henderson JM. Management of variceal bleeding in patients with extrahepatic portal vein thrombosis. Am J Surg 1990;160:122-27.
  22. Robson SC, Kahn D, Kruskal J, et al. Disordered hemostasis in extrahepatic portal hypertension. Hepatology 1993;18:853-57.
  23. Vandenbroucke JP, Koster T, Briеt E, et al. Increased risk of venous thrombosis in oral contraceptive users who are carriers of factor V Leiden mutation. Lancet 1994;344:1453-57.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies