EFFEKTIVNOST' GEPTRALA® V LEChENII PEChENOChNOY TOKSIChNOSTI, OBUSLOVLENNOY TsITOSTATIChESKOY KhIMIOTERAPIEY
- Authors: Snegovoy AV1, Manzyuk LV1
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Affiliations:
- Issue: No 6 (2010)
- Pages: 56-61
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/278361
- ID: 278361
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Abstract
У 19 пациентов с различными злокачественными опухолями проведена оценка эффективности препарата Гептрал® (адеметионин) при лечении гепатотоксичности, индуцированной химиотерапией. Показано, что при 4-недельном приеме Гептрала® внутрь по 400 мг 2 раза в день уровень трансаминаз снизился до нормы у 10 из 12 пациентов с 1-й степенью гепатотоксичности. Для нормализации уровня трансаминаз при 2-й степени гепатотоксичности потребовался более длительный прием Гептрала® (от 2 до 4 месяцев). Режим химиотерапии в период применения Гептрала® не менялся.
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References
- King PD, Perry MC. Hepatoioxiciry of chemotherapy. The Oncologist 2001;6:162-76.
- DeLeve LD, Kaplovitz N. Mechanisms of drug-induced liver disease. Gastroenterol Clin North Am 1995;24:787-810.
- Dansette PM, Bonierbale E, Minoletti С, et al. Drug-induced immunotoxicity. Eur J Drug Metab Pharmacokinet 1998;23:443-51.
- Kaplowitz N, Aw TY, Simon FR et al. Drug-induced hepatotoxicity. Ann Intern Med 1986;104:826-39.
- Ishak KG, Zimmerman HJ. Morphologic spectrums of drug-induced liver disease. Gastroenterol Clin North Am 1995;24:759-86.
- Larrey D. Drug-induced liver diseases. J Hepatol 2000;32:77-88.
- Zorti D, et al. Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases. Br J Surgery 2007;94:274-86.
- Paul D, et al. Hepatotoxicity of chemotherapy. The Oncologist 2001;6:162-76.
- O' Grady JG. Paracetamol-induced acute liver failure: prevention and management. J Hepatol 1997;26:41-46.
- Strieker BH. Drug-induced Hepatic Injury. 2nd edn. Amsterdam: Elsevier, 1992.
- Pessayre D, Larrey D, Biour M. Drug-induced liver injury. Oxford Textbook of Clinical Hepatology, 2nd edn. Oxford University Press 1999;2:1261-315.
- Hirata F, Viveros OH, Diliberto EJ. Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine. Proc Natl Acad Sci USA 1978;75:1718-21.
- Kretzschmar M, Klinger W. The hepatic glutathione system influences of xenobiotics. Exp Pathol 1990;38:145-64.
- Cabrero C, Duce AM, Ortiz P, et al. Specific loss of the high-molecular-weight form of S-adenosyl-L-methionine synthetase in human liver cirrhosis. Hepatology 1988;8:1530-34.
- Cantoni GL. The nature of the active methyl donor formed enzymically from L-methionine and adenosine triphosphate. J Am Chem Soc 1952;74:2942-43.
- Dunne JB, Davenport M, Williams R, et al: Evidence that S-adenosylmethionine and N-acetylcysteine reduce injury from sequential cold and warm ischaemia in the isolated perfused rat liver. Transplantation 1994;57:1161-68.
- Mato JM, Camara J, Fernandez de Paz J, et al. Adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol 1999;30:1081-89.
- Giudici GA, Le Grazie С, Di Padova C. The use of ademethionine (SAMe) in the treatment of cholestatic liver disorders: meta-analvsis of clinical trials. Methionine Metabolism: Molecular Mechanism and Clinical Implications. Madrid: CSIC Press pp 1992;67-9.
- Feliu J, Mel JR, Camps C, et al. Raltitrexed in the treatment of elderly patients with advanced colorectal cancer. An active and low toxicity regimen. Eur J Cancer 2002;З8:1204-11.
- Cascinu S, Graziano F, Ferrau F, et al. Raltitrexed plus oxaliplatin (TOMOX) as first-line chemotherapy for metastatic colorectal cancer. A phase II study of the Italian Group for the Study of Gastrointestinal Tract Carcinomas (GISCAD). Ann Oncol 2002;13:716-20.