ИСПОЛЬЗОВАНИЕ НИМОДИПИНА (НИМОТОПА) ПРИ КОГНИТИВНЫХ НАРУШЕНИЯХ
- Авторы: Дамулин ИВ1, Damulin IV2
-
Учреждения:
- Кафедра нервных болезней ММА им. И.М. Сеченова, Москва
- Выпуск: № 7 (2010)
- Страницы: 32-38
- Раздел: Статьи
- URL: https://journals.eco-vector.com/2073-4034/article/view/278374
- ID: 278374
Цитировать
Полный текст
Аннотация
В статье рассматриваются механизмы действия и клинический эффект блокатора кальциевых каналов нимодипина. Подчеркивается, что в настоящее время этот препарат применяют при субарахноидальном кровоизлиянии, ишемическом инсульте и деменциях различного (сосудистого и первично-дегенеративного) генеза. Этот препарат не только действует симптоматически, улучшая когнитивные и поведенческие функции у пациентов с деменцией, но и способен влиять на механизмы развития когнитивных расстройств. Побочные эффекты на фоне терапии встречаются редко, что представляется особенно важным для пациентов пожилого и старческого возраста.
Об авторах
И В Дамулин
Кафедра нервных болезней ММА им. И.М. Сеченова, МоскваКафедра нервных болезней ММА им. И.М. Сеченова, Москва
I V Damulin
Список литературы
- Андреев Н.А., Моисеев В.С. Антагонисты кальция в клинической медицине. М., 1995. 161 с.
- Козловский В.Л. Влияние блокаторов кальциевых каналов на эффективность галоперидола и фенамина у мышей и крыс // Экспериментальная и клиническая фармакология. 1996. Т. 59. С. 12-15.
- Стаховская Л.В., Чекнева Н.С. Нимотоп С в лечении цереброваскулярной патологии. Методические рекомендации / Под ред. Л.Г. Ерохиной. М., 1995. 20 с.
- Яхно Н.Н. Когнитивные расстройства в неврологической клинике // Неврологический журнал. 2006. Т. 11. Прилож. 1. С. 4-12.
- Avery RB, Johnston D. Multiple channel types contribute to the low-voltage-activated calcium current in hippocampal CA3 pyramidal neurons. J Neurosci 1996;16:5567-82.
- Ban TA, Morey L, Aguglia E, et al. Nimodipine in the treatment of old age dementias. Prog Neuro-Psychopharmacol Biol Psychiatr 1990;14:525-51.
- Besson JAO, Palin AN, Ebmeyer KP, et al. Calcium antagonists and multi-infarct dementia: a trial involving sequential NMR and psychometric assessment. Intern J Geriatr Psychiatry 1988;3:99-105.
- Campbell LW, Hao SY, Thibault O, et al. Aging changes in voltage-gated calcium currents in hippocampal CA1 neurons. J Neurosci 1996;16:6286-95.
- De Riu PL, Demontis MP, Anania V, et al. Brain electrobiogenesis protection induced by nimodipine and MK-801 during acute hypoxia in hypertensive rats. Pharmacol Res 1995;31:169-73.
- Eicher H, Hilgert D, Zeeh J, et al. Pharmacokinetics of nimodipine in multimorbid elderly patients with chronic brain failure. Arch Gerontol Geriatr 1992;14:309-19.
- Ercan M, Inci S, Kilinc K, et al. Nimodipine attenuates lipid peroxidation during the acute phase of head trauma in rats. Neurosurg Rev 2001;24:127-30.
- Erkinjuntti T. Subcortical vascular dementia - diagnostic problems. In: 7th IPA Congress. Sydney, Australia, 1995:45.
- Ferszt R, Kanowski S. Nimodipine in the treatment of dementia. Drugs Today 1998;34:767-76.
- Frisoni GB, Galluzzi S, Bresciani L, et al. Mild cognitive impairment with subcortical vascular features. Clinical characteristics and outcome. J Neurol 2002;249:1423-32.
- Grobe-Einsler R. Clinical aspects of nimodipine. Neurobiol Aging 1993;13:S39-45.
- Hauerberg J, Rasmussen G, Juhler M, et al. The effect of nimodipine on autoregulation of cerebral blood flow after subarachnoid haemorrhage in rat. Acta Neurochir (Wien) 1995;132:98-103.
- Herz RC, De Wildt DJ, Versteeg DH. The effects of gamma 2-melanocyte-stimulating hormone and nimodipine on cortical blood flow and infarction volume in two rat models of middle cerebral artery occlusion. Eur J Pharmacol 1996;306:113-21.
- Kabuto H, Yokoi I, Mori A. Neurochemical changes related to ageing in the senescence-accelerated mouse brain and the effect of chronic administration of nimodipine. Mech Ageing Dev 1995;80:1-9.
- Kanowski S, Fischhov P, Hiersemenzel R, et al. Therapeutic efficacy of nootropic drugs - a discussion of clinical phase III studies with nimodipine as a model. In: Diagnosis and treatment of senile dementia. M. Bergener, B. Reisberg (Eds.). Berlin etc.: Springer-Verlag 1989:339-49.
- Kazda S, Gartoff B, Krause HP, et al. Cerebrovascular effects of calcium antagonistic dihydropyidine deriviative nimodipine in animal experiments. Drugs Res 1982;32:331-38.
- Korenkov AI, Pahnke J, Frei K, et al. Treatment with nimodipine or mannitol reduces programmed cell death and infarct size following focal cerebral ischemia. Neurosurg Rev 2000;23:145-50.
- Knopman DS. Treatment of mild cognitive impairment and prospects for prevention of Alzheimer's disease. In: Mild Cognitive Impairment: Aging to Alzheimer's Disease. Ed. by R.C.Petersen. Oxford: Oxford University Press 2003:243-58.
- Landfield PW. Calcium homeostasis in brain ageing and Alzheimer's disease. In: Diagnosis and Treatment of Senile Dementia. Ed by. M.Bergener, B.Reisberg. Berlin: Springer Verlag 1989:276-87.
- Levere TE, Walker A. Old age and cognition enhancement of recent memory in aged rats by the calcium channel blocker nimodipine. Neurobiol Aging 1991;13:63-66.
- Lopez-Arrieta J. Nimodipine. /In: Evidence-based Dementia Practice. Ed. by N.Qizilbash et al. Oxford: Blackwell Science 2002:537-40.
- Luiten PG, Douma BR, Van der Zee EA, et al. Neuroprotection against NMDA induced cell death in rat nucleus basalis by Ca2+ antagonist nimodipine, influence of aging and developmental drug treatment. Neurodegeneration 1995;4:307-14.
- Lustig HS, Ahern KB, Greenberg DA. Omega-agatoxin IVA and excitotoxicity in cortical neuronal cultures. Neurosci Lett 1996;213:142-44.
- Nomura M. Effect of nimodipine on brightness discrimination learning test in Wistar Kyoto and spontaneously hypertensive rats. Drugs Res 1988;38:1282-86.
- Noskovic P, Faberova V, Fabianova M. Effect of a combination of pentoxifylline and nimodipine on lipid peroxidation in postischemic rat brain. Mol Chem Neuropathol 1995;25:97-102.
- Pantoni L, Rossi R, Inzitari D, et al. Efficacy and safety of nimodipine in subcortical vascular dementia: a subgroup analysis of the Scandinavian Multi-Infarct Dementia Trial. J Neurol Sci 2000;175:124-34.
- Pantoni L, del Ser T, Soglian AG, et al. Efficacy and safety of nimodipine in subcortical vascular dementia: a randomized placebo-controlled trial. Stroke 2005;36:619-24.
- Sandin M, Jasmin S, Levere T. Aging and cognition. Facilitation of recent memory in aged nonhuman primates by nimodipine. Neurobiol Aging 1990;11:573-75.
- Scriabine A. Pharmacology overview: Nimodipine in CNS indications. In: Nimodipine: Pharmacological and clinical results in cerebral ischemia. A.Scriabine et al (Eds.). Berlin etc.: Springer-Verlag 1991:1-7.
- Sobrado M, Lopez MG, Carceller F, et al. Combined nimodipine and citicoline reduce infarct size, attenuate apoptosis and increase bcl-2 expression after focal cerebral ischemia. Neuroscience 2003;118:107-13.
- Stuiver BT, Douma BR, Bakker R, et al. In vivo protection against NMDA-induced neurodegeneration by MK-801 and nimodipine: combined therapy and temporal course of protection. Neurodegeneration 1996;5:153-59.
- Sze KH, Sim TC, Wong E, et al. Effect of nimodipine on memory after cerebral infarction. Acta Neurol Scand 1998;97:386-92.
- Tollefson GD. Short-term effects of the calcium channel blocker nimodipine (Bay-e-9736) in the management of primary degenerative dementia. Biol Psychiatr 1990;27:1133-42.
- Tomassoni D, Lanari A, Silvestrelli G, et al. Nimodipine and its use in cerebrovascular disease: evidence from recent preclinical and controlled clinical studies. Clin Exp Hypert 2008;30:744-66.
- Viveros MP, Martin S, Ormazabal M, et al. Effects of nimodipine and nifedipine upon behavior and regional brain monoamines in the rat. Psychopharmacology (Berl.) 1996;127:123-32.
- Yanpallewar SU, Hota D, Rai S, et al. Nimodipine attenuates biochemical, behavioral and histopathological alterations induced by acute transient and long-term bilateral common carotid occlusion in rats. Pharmacol Res 2004;49:143-50.
Дополнительные файлы
