CORRELATION OF CARDIOHEMODYNAMICS INDICES, INFLAMMATORY CYTOKINES LEVELS AND DEPRESSIVE DISORDERS IN PATIENTS WITH CHRONIC HEART FAILURE


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The content of proinflammatory cytokines, the prevalence and severity of depression in patients with chronic heart failure were explored. It was noted that the morphological and functional parameters of the myocardium and the content of cytokines are related. Increased content of interleukin-1β, interleukin-6 and tumor necrosis factor α, and depressive disorders were detected significantly more frequently in patients with left ventricular hypertrophy in comparison with patients with normal geometry of the myocardium. Maximum production of proinflammatory cytokines and the greatest severity of depression occurred in patients with a pronounced decrease in myocardial contractility.

参考

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