CHRONIC VITAMIN A INTOXICATION AS A CAUSE OF HEPATIC CIRRHOSIS


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Abstract

The article presents clinical observation of hepatic cirrhosis caused by vitamin A intoxication as a result of its long-term uncontrolled use. The mechanisms of organ damage during intoxication with vitamin A are discussed.

References

  1. Goodman DS. Vitamin A and retinoids in health and disease. N Engl J Med 1984;310(16):1023-31.
  2. Hopkins FG. Feeding experiments illustrating the importance of accessory factors in normal dietaries. J Physiol 1912;44:425-60.
  3. McCollum EV. Early experiences with vitamin A Retrospect. Nutr Rev 1952;10(6):161-63.
  4. McCollum EV. The paths to the discovery of vitamins A and D. J Nutr 1967;91(2):32-38.
  5. Moro JR, Iwata M, von Andriano UH. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol 2008;8(9):685-98.
  6. Van DE, Kulier R, Gülmezoglu AM, et al. Vitamin A supplementation during pregnancy. Cochrane Database Syst Rev 2002;4:CD001996.
  7. Черкес Л.А. Н.И.Лунин и начальные этапы развития витаминологии // Архив патологии 1955. № 17(1). C. 69-75.
  8. Wolf G, Carpenter KJ. Early research into the vitamins: the work of Wilhelm Stepp. J Nutr 1997;127:1255-59.
  9. Karrer P, Morf R, Schöpp K. Zur Kenntnis des Vitamins-A aus Fischtranen. Helv Chim Acta 1931;14:1036.
  10. Friedrich W. Vitamins. Ed. Walter de Gruyter 1988;63-66.
  11. Roels OA. The fifth decade of vitamin A research. Am J Clin Nutr 1969;22(7):903-07.
  12. Vitamin basics. DSM 2007;9-14.
  13. Rodahl K, Moore T. The vitamin A content and toxicity of bear and seal liver. Biochem J 1943;37(2):166-68.
  14. Rodahl K, Davies AW. Vitamin A in seals. Biochem J 1949;45(4):408-12.
  15. Leicht E, Strunz J, von Seebach HB, et al. Acute vitamin A intoxication with hemolytic anemia, hypercalcemia and toxic hepatosis. Med Klin 1973;68(2):54-59.
  16. Harrison's Principles of Internal Medicine, 16th Ed 407-408, 2258
  17. Lam HS, Chow CM, Poon WT, et al. Risk of vitamin A toxicity from candy-like chewable vitamin supplements for children. Pediatrics 2006;118(2):820-24.
  18. Azzam R, Dilley K, Melin-Aldana H, et al. Clinical quiz. Chronic vitamin A intoxication. J Pediatr Gastroenterol Nutr 2005;41(3):363-65.
  19. Sheth A, Khurana R, Khurana V. Potential liver damage associated with over-the-counter vitamin supplements. J Am Diet Assoc 2008;108(9):1536-37.
  20. Yamamoto M. Toxic hepatitis induced by vitamin A. Nippon Rinsho 1985;43(6):1187-91.
  21. Geubel AP, Rahier J. Hypervitaminosis A: physiopathology and liver toxicity. Rev Med Liege 1983;38(18):679-84.
  22. Rubin E., Florman A.L., Degnan T., Diaz J. Hepatic injury in chronic hypervitaminosis A. Am J Dis Child 1970;119(2):132-38.
  23. Prakash R. The acute and chronic toxic effects of vitamin A. Am J Clin Nutr 2006;84(2):462.
  24. Харкевич Д.А. Фармакология. М., 2002. C. 474-77.
  25. Allen LH, Haskell M. Estimating the potential for vitamin A toxicity in women and young children. J Nutr 2002;132(9):2907-19.
  26. Mahoney CP, Margolis MT, Knauss TA, et al. Chronic vitamin A intoxication in infants fed chicken liver. Pediatrics 1980;65(5):893-97.
  27. Kowalski TE, Falestiny M, Furth E, et al. Vitamin A hepatotoxicity: a cautionary note regarding 25,000 IU supplements. Am J Med 1994;97:523-28.
  28. Nollevaux MC, Guiot Y, Horsmans Y, et al. Hypervitaminosis A-induced liver fibrosis: stellate cell activation and daily dose consumption. Liver Int 2006;26(2):182-86.
  29. Kistler HJ, Pluer S, Dickenmann W, et al. Portal hypertension without liver cirrhosis in chronic citamin A intoxication. Schweiz Med Wochenschr 1977;107(24):825-32.
  30. Hendriks HF, Bosma A, Brouwer A. Fat-storing cells: hyper- and hypovitaminosis A and the relationships with liver fibrosis. Semin Liver Dis 1993;13(1):72-80.
  31. Noyan S, Cavusoglu I, Minbay FZ. The effect of vitamin A on CCl4- induced hepatic injuries in rats: a histochemical, immunohistochemical and ultrastructural study. Acta Histochem 2006;107(6):421-34.
  32. Miksad R, de Ledinghen V, McDougall C, et al. Hepatic hydrothorax associated with vitamin A toxicity. J Clin Gastroenterol 2002;34(3):275-79.
  33. Jacques EA, Buschmann RJ, Layden TJ. The histopathologic progression of vitamin A-induced hepatic injury. Gastroenterology 1979;76(3):599-602.
  34. Muenter MD, Perry HO, Ludwig J. Chronic vitamin A intoxication in adults. Hepatic, neurologic and dermatologic complications. Am J Med 1971;50(1):129-36.
  35. Guarascio P, Portmann B, Visco G, et al. Liver damage with reversible portal hypertension from vitamin A intoxication: demonstration of Ito cells. J Clin Pathol 1983;36(7):769-71.
  36. Hruban Z, Russell RM, Boyer JL, et al. Ultrastructural changes in livers of two patients with hypervitaminosis A. Am J Pathol 1974;76(3):451-61.
  37. Russell RM, Boyer JL, Bagheri SA, et al. Hepatic injury from chronic hypervitaminosis a resulting in portal hypertension and ascites. N Engl J Med 1974;291(9):435-40.
  38. Minuk GY, Kelly JK, Hwang WS. Vitamin A hepatotoxicity in multiple family members. Hepatology 1988:8(2):272-75.
  39. Rosenbaum J, Amedee-Manesme O, Dhumeaux D. The liver and vitamin A. Gastroenterol Clin Biol 1985;9(3):255-62.
  40. Zafrani ES, Bernuau D, Feldmann G. Peliosis-like ultrastructural changes of the hepatic sinusoids in human chronic hypervitaminosis A: report of three cases. Hum Pathol 1984;15(12):1166-70.
  41. Geubel AP, De Galocsy C, Alves N, et al. Liver damage caused by therapeutic vitamin A administration: estimate of dose-related toxicity in 41 cases. Gastroenterology 1991;100(6):1701-9.
  42. Castano G, Etchart C, Sookoian S. Vitamin A toxicity in a physical culturist patient: a case report and review of the literature. Ann Hepatol 2006;5(4):293-95.
  43. Maroy B, Moullot P, Constantin JM. Probable side effects caused by plethoryl. Common acute hepatitis, anicteric hepatitis, cirrhosis due to hypervitaminosis A, inflammatory arthralgias. Presse Med 1989;18(11):567-70.
  44. Canbay A, Taimr P, Torok N, et al. Apoptotic body engulfment by a human stellate cell line is profibrogenic. Lab Invest 2003;83:655-63.
  45. Becker P, Maurer B, Schirmacher P, et al. Vitamin A-induced cholestatic hepatitis: a case report. Z Gastroenterol 2007;45(10):1063-66.
  46. Oren R, Ilan Y. Reversible hepatic injury induced by long-term vitamin A ingestion. Am J Med 1992;93(6):703-4.
  47. Farrell GC, Bhathal PS, Powell LW. Abnormal liver function in chronic hypervitaminosis A. Am J Dig Dis 1977;22(8):724-28.
  48. Weber FL Jr, Mitchell GE Jr, Powell DE, et al. Reversible hepatotoxicity associated with hepatic vitamin A accumulation in a protein-deficient patient. Gastroenterology 1982;82(1):118-23.
  49. Theiler R, Wirth HP, Flury R, et al. Chronic vitamin A poisoning with musculoskeletal symptoms and morphological changes of the liver: a case report. Schweiz Med Wochenschr 1993;123(51-52):2405-12.

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