RECURRENT POLYSINUSITIS AS LEADING CLINICAL SIGN OF CYSTIC FIBROSIS: SUCCESSFUL ENDONASAL USE OF DORNASE ALFA
- Authors: Asherova IK1, Tarakanova VV1, Asherova I.K.1, Tarakanova V.V.1
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- Issue: No 14 (2010)
- Pages: 66-68
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/278589
- ID: 278589
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Abstract
The present article is dedicated to the case of delayed diagnosis of cystic fibrosis (CF) in 6 years old patient with recurrent polysinusitis treated in pulmonological hospital. Diagnosis of CF was confirmed by genetic research. In the represented case history, polysinusitis was the basic clinical presentation of CF, relegating to the background upper respiratory tract symptoms, but which were recognized by careful examination. It was noted that Pulmozim (Dornase alfa) has distinct positive effect, allowing to achieve complete recovery of nasal breathing, hearing, and improvement of quality of life.
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About the authors
I K Asherova
V V Tarakanova
Irina Karlovna Asherova
Valentina Viktorovna Tarakanova
References
- Муковисцидоз (современные достижения и актуальные проблемы) методические рекомендации под редакцией проф. Н.И. Капранова, проф. Н.Ю.Каширской. М., 2005. 124 с.
- Mainz JG, Koitchev A. Management of chronic rhinosinusitis in cystic fibrosis. J Cystic Fibrosis 2009;8S:S10-S14.
- Mainz JG, Mentzel HJ, Schneider G, et al. Sinu-nasal inhalation of dornase alfa in CF. Results of a double-blind placebo-controlled pilot trial. J Cystic Fibrosis 2008;7:27 (abstract).
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