NEUROLOGICAL ASPECTS OF HIV INFECTION


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Abstract

The article is dedicated to the problem of neurocognitive disorders (VAND) in HIV infection that are making major contributions to clinical disease. It is noted that the incidence of VAND reaches 80% and varies depending on the severity of neurological disorders. The risk factors for VAND are presented; role of HIV replication in cerebrospinal fluid (CSF) is discussed. Control of virus replication in the CSF may play an important role both in prevention of VAND and the recovery of drug-resistant mutant viruses. Therefore, in recent years the ability of different antiretroviral drugs to penetrate the blood-brain barrier into the CNS has particular significance. It is emphasized that client-centered approach and optimized antiretroviral therapy with account of penetration of the blood-brain barrier may provide effective treatment of symptoms of CNS involvement and improvement of clinical outcomes.

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