UNIQUE ROLE of ADEMETIONINE IN CELL METABOLISM AND ITS PHARMACOLOGICAL POTENTIAL


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Abstract

The article presents an overview of the biochemical properties of ademetionine, which has active multilateral effects on the cell metabolism. The pharmacological activity of preparations containing ademetionine as an active substance was assessed and prospects of development of new drugs were shown. In particular, ademetionine can modulate apoptosis in normal and proliferating hepatocytes, and in this respect ademetionine is potential agent for chemotherapy of hepatocellular carcinoma. Due to anti-inflammatory and regenerating properties, ademetionine may be used in intensive care units and in burns centers.

References

  1. Friedel HA, Goa KL. Benfield P. S-adenosyl-L-Methionine. A Review of its Pharmacological Properties end Therapeutic Potential in Liver Dysfunction and Affective Disorders in relation to its Physiological Role in cell Metabolism. Drugs 1989;38(3):389-416.
  2. Мс Daniel BA, Grundy FJ, Artsimowich I, et al. Transcription termination control of the S box system: direct measurement of S-adenosylmethionine by the leader RNA. Proc Natl Acad Sci USA 2003;100:3083-88.
  3. Whitford PC, Schug A, Saunders J, et al. Nonlocal helix formation is key to understanding S-adenosylmethionine-1 ribowitch function. Biophys J 2009;96:L7-L9.
  4. Wang SC, Frey PA. S-adenosylmethionine as an oxidant: the radical SAM superfamily. Trends Biochem Sci 2007;32(5):209-15.
  5. McGlyn SE, Boyd ES, Shepard EM, et al. Identification and Characterization of Novel Member of the Radical AdoMet Enzyme Superfamily and Implications for the Biosynthesis of the Hmd Hydrogenase Active Site Cofactor. J Bacteriology 2010:595-98.
  6. Prudova A, Bauman Z, et al. Banerjee R. AdoMet regulation of cystathionine - β-synthase: relevance to oxidative stress in liver disease. Proc Natl Acad Sci USA 2006;103:6489-94.
  7. Corrales F, Ochoa P, Rivas G, et al. Inhibition of glutathione synthesis in the liver leads to S-adenosil-L-metionine synthetasereduction. Hepatology 1991;14:528-33.
  8. Mato JM, Lus SC. Role S-adenosyl-L-methionine in liver health and injury. Hepatology 2007;45:1306-12.
  9. Caro AA, Cedebraum AI. Antioxidant properties of S-adenosyl-L-methionine in Fe2+-initiated oxidations. Free Radical Biol Med 2004;36(10):1303-16.
  10. Erdman K, Cheung B, Immenschuh S, et al. Heme oxigenase-1 - is a novel target and antioxidant mediator of S-adenosylmethionine. Biochem Biophys Res Commun 2008;368:937-41.
  11. Lu SC, Mato JM. S-Adenosylmethionine in cell growth, apoptosis ans liver cancer. J Gastroenterol Hepatol 2007;23:73-77.
  12. Мирошниченко И.И., Птицина С.Н. Кузнецова Н.Н. и др. Гомоцистеин - предиктор патологических изменений в организме человека // РМЖ. 2009. Т. 17. № 4(343). С. 224-27.
  13. Bottiglieri T. Effect S-adenosylmethionine on Blood Homocysteine. 2010 http://ww.baylorhealth.edu/Research/Grants/bloodhomocysteine.htm.
  14. Dayal S, Rodionov RN, Arning E, et al. Endothelial dysfunction and tissue specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemic mice. J Physiol Heart Circ Physiol 2008;295:816-25.
  15. Мирошниченко И.И., Птицина С.Н. Биомаркеры в современной медико-биологической практике // Биомедицинская химия. 2009. Т. 55. Вып. 4. С. 425-40
  16. Cedebraum AI, Lu Y, Wu D. Role of oxidative stress in alcohol-induced liver injury. Arch Toxicol 2009;83:519-48.
  17. Sherlock S. Cholestasis: definition and classification of the major clinical forms. In: Gentini P. Arias M., Mcintire N and Rodes J. (Eds), Elsevier Science: Cholestasis. Amsterdam 1994:3-18.
  18. Lee TD, Sadda ME, Mendler MH. Abnormal hepatic metionine ans GSH metabolism in patients with alcoholic hepatitis. Alcohol Clin Esp Res 2004;28:173-81.
  19. Голованова Е.В. Диагностика и лечение внутрипеченочного холестаза при хронических заболеваниях печени. Труды XVI Российского национального конгресса "Человек и лекарство". М., 2010. Т. 1. С. 154-69.
  20. Горьков В.А., Раюшкин В.А., Олейчик И.В. и др. Феномен гептрала: депрессии, абстинентный синдром, холестаз, артралгии: взгляд фармаколога // Психиатрия и психофармакотерапия. 2000. Т. 2. № 6. С. 176-78.
  21. Burrows RF, Clavisi O, BurrowsE. Interventiones for Treating cholestasis in pregnancy. Cochrane Datebase Syst Rev 2001;4:CD000493.
  22. Lammert F, Marshall HU, Matern S. Intrahepatic Cholestasis of Pregnancy. Curr Treat Options Gastroenterol 2003;6(2):123-32.
  23. Huang JY, Liu H. Analysis therapeutic effect of Western and Chinese drug in treating intrahepatic cholestasis pregnancy. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004;24(4):309-11.
  24. Roncaglia N, Locatelli A, Arreghini A, et al. A randomized controlled trial of ursodeoxycholic acid and S-adenosyl-1-methionine in the treatment of gestational cholestasis. BJOG 2004;111(1):17-21.
  25. Cozen DD, Barton SJ, Clark R, et al. Reproductive toxicity studies of ademetionine. Arzneimittelforschung 1988;38(11):1625-29.
  26. Janicak PG, Lipinski J, Davis JM, et al. S-adenosylmethionine in depression. A literature revier and preliminary report. J Med Sciences 1988;25:306-13.
  27. Bressa GM. S-adenosyl-L-methionine (SAM) as antidepressant: meta-amalysis of clinical studies. Acta Neurol Scand 1994;89:4-14.
  28. Смулевич А.Б., Дубницкая Э.Б., Иванов С.В. Опыт и перспективы применения гептрала при терапии депрессий // Психиатрия и психофармакотерапия. 2002. Т. 4. № 3. С. 99-103
  29. Seyoum G, Persaud TV. In vitro effect S-adenosyl methionine on etanol embryopathy in the rat. Exp Toxicol Pathol 1994;46(3):177-81.
  30. Purohit V, Abdelmalek MF, Barve S, et al. Role S-adenosylmethionine, folate and Betaine in the treatment of alcoholic liver disease: summary of symposium 1-4. 2006.

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