EFFECT OF LONG-TERM ANTIOXIDANT THERAPY WITH N-ACETYLCYSTEINE ON OXIDATIVE STRESS INDICES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

The dynamics of free-radical lipoperoxide processes and antioxidant activity of blood plasma in 62 patients with stable chronic obstructive pulmonary disease (COPD) of different severity against the background of prolonged use of high-dose N-acetylcysteine in the combination treatment of disease were assessed. It was noted that lipoperoxide processes, reflecting the intensity of oxidative stress, were more pronounced among patients with COPD who not received inhaled corticosteroids (ICS). On the background of long-term antioxidant treatment of COPD with high-dose N-acetylcysteine, intensity of oxidative stress has decreased, and the antioxidant effect of treatment was significantly more pronounced in patients received ICS. This was accompanied by decrease in respiratory symptoms and increase in exercise tolerance. It is emphasized that the inclusion of high-dose N-acetylcysteine (1200 mg/day) in the combination treatment of stable COPD with the aim of suppression of oxidative stress is efficient for patients receiving ICS, i.e. patients with severe and very severe COPD.

chronic obstructive pulmonary disease, oxidative stress, antioxidant therapy, N-acetylcysteine, inhaled glucocorticosteroids