PROSPECTS FOR THE USE OF BLOOD APOLIPOPROTEINS FOR DRUG TRANSPORT THROUGH THE BLOOD-BRAIN BARRIER IN ORDER TO THE EMPOWERMENT OF PHARMACOTHERAP
- Authors: Shamenkov D.A.1, Svistunov A.A.1, Shamenkov D1, Svistunov A1
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- Issue: No 20 (2010)
- Pages: 95-98
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/278744
- ID: 278744
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Abstract
Blood-brain barrier prevents the transport of drugs into the central nervous system. This limits the possibilities of therapy for many diseases. Thus, the drug transport across the blood-brain barrier remains one of the key problems of modern pharmacology. This study investigated the possibility of using blood apolipoproteins to increase of dalargin transport through the bloodbrain barrier. Antinociceptive activity of dalargin (7,5 mg/kg) adsorbed on nanoparticles with different coating was studied on outbred albino mice by the tail-flick test. Delivery of dalargin to the brain was most effective and safe in case of using nanoparticles with apolipoprotein E coating.
About the authors
Dmitriy Alekseevich Shamenkov
Andrey Alekseevich Svistunov
D Shamenkov
A Svistunov
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