DORNASE ALPHA (PULMOZYME) FOR THE COMPLEX TREATMENT OF BRONCHOPULMONARY PROCESS IN CYSTIC FIBROSIS PATIENTS.


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The article describes current understanding of the pathogenesis and clinical course of cystic fibrosis (CF). The modern treatment options for cystic fibrosis using Pulmozyme® (dornase alfa), a purified solution of recombinant human deoxyribonuclease 1, produced by the pancreas and other tissues, are discussed. The results of evaluation of safety and efficacy of dornase alfa in 108 children of different age groups with moderate and severe disease observed in the Russian Center of Cystic Fibrosis are presented. It is emphasized that in addition to mucolytic effect, dornase alfa has a number of nonmucolitic effects, such as reduction of neutrophil elastase and interleukin-8 concentrations in the sputum of patients with mucoid Pseudomonas aeruginosa, and inhibition of the formation of mucoid Pseudomonas aeruginosa biofilms determining antibiotic resistance and immune response. It was found that the intranasal administration of Pulmozyme in CF patients with chronic rhinosinusitis
is effective.

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