MODERN CONCEPTS OF DIAGNOSIS AND TREATMENT OF FUNCTIONAL DYSPEPSIA


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Abstract

Functional dyspepsia (FD) is widespread chronic disease in the world. It is manifested by abdominal pain or discomfort in the absence of a clear organic cause, which could be determined during the detailed examination. Rome III criteria have presented a definition of FD and versions of its course - postprandial distress syndrome and epigastric pain. Multiple mechanisms, such as delayed gastric emptying, impaired gastric accommodation, increased exposure of hydrochloric acid, visceral hypersensitivity and dysfunction of the central nervous system, are probably involved in the pathogenesis of FD. Although the possibilities of drug therapy of FD are still limited, the experience of use of proton pump inhibitors, prokinetics, tricyclic antidepressants, and a number of alternative methods for the treatment of this disease is accumulated.

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