APPLICATION OF THIOCTIC ACID IN NONALCOHOLIC STEATOHEPATITIS
- Autores: Russkikh A.V.1, Russkikh AV1
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Afiliações:
- Edição: Nº 12 (2011)
- Páginas: 87-92
- Seção: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/278947
- ID: 278947
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Resumo
70% of patients with non-alcoholic steatohepatitis (NASH) experienced insulin-dependent diabetes mellitus, and the remaining 30% of patients experienced glucose intolerance in different periods of the disease. Decrease in the sensitivity of tissue receptors to insulin is a pathogenetic basis of NASH associated with heredity. Thioctic acid prevents the development of fatty liver disease and is a regulator of the number and functionality of membrane receptors, including insulin receptors. Ursodeoxycholic acid, metformin, and thioctic acid (Thiogamma) is well-studied, optimal and safe combination for the integrated pathogenetic treatment of NASH. Participation of thioctic acid in the antioxidant defense allows of conclusion about the advisability of administration of Thiogamma in all patients with elevated body mass index and insulin resistance for the prevention and treatment of hepatic steatosis and NASH.
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Bibliografia
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