AGGRAVATION OF EPILEPTIC NEGATIVE MYOCLONUS AGAINST THE BACKGROUND OF USE OF CARBAMAZEPINE AND OXCARBAZEPINE IN CHILDREN


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Abstract

Epileptic negative myoclonus (ENM) is one of the rare types of epileptic seizures in children. ENM is defined as a sudden sharp interruption of tonic muscular activity simultaneously with epileptiform discharges on EEG without prior myoclonic component. The results of study of anamnestic, clinical, electroencephalographic and neuroimaging features of patients with ENM induced by use of carbamazepine and oxcarbazepine are presented. Risk factors for aggravation of ENM in patients receiving carbamazepine/oxcarbazepine are identified. It is emphasized that administration of the carbamazepine/oxcarbazepine should be limited in idiopathic focal epilepsy, focal epilepsy syndrome of childhood with the structural changes in the brain and benign epileptiform EEG discharges (BEDC), epileptic encephalopathies associated with BEDC, symptomatic focal epilepsy with secondary bilateral synchronization phenomena on EEG, progressive myoclonus epilepsy, especially in preschool children.

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