BIOPREPARATY I PRIONNYE BOLEZNI, VOZMOZhNA LI ETIOLOGIChESKAYa SVYaZ'?


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Abstract

The literature review reflects the current data of foreign researchers on the nature and biological properties of the prion proteins, and their conformational variations. Information about the role of cellular prion protein in the functioning of various tissues and body systems, and ways of infection by abnormal prion isoforms is presented. Pathological changes and clinical manifestations of prion diseases in humans are described; current classification of prion diseases is presented. Preventive measures and methods for the prevention of extension of prion diseases as well as modern methods of laboratory diagnosis are described in detail. The probability of infection through the use of a biological product, depending on the characteristics of its constituent agents and the processing method of the native material, which served as the basis for its creation, is estimated.

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