PREVENTION OF ADVERSE OUTCOMES OF RHEUMATOID ARTHRITIS: MODERN THERAPEUTIC STRATEGY


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Abstract

The article discusses the problem of modern therapeutic tactics in the treatment of rheumatoid arthritis (RA), a one of the most serious human diseases. The practice in the early application of the disease-modifying anti-rheumatic drugs (DMARDs) for improvement of long-term outcomes of the disease, which became possible after the development of new diagnostic criteria EULAR / ACR (2010) for RA is considered. International recommendations for management of patients with early arthritis and for the treatment strategies for RA are presented. Particular attention is given to a new class of drugs for the treatment of RA - genetically engineered biological substances that have an impact on the various links of the pathogenesis of the disease directly in the synovium and are used in combination therapy with DMARDs, particularly methotrexate. Thus, improvement of long-term outcomes of RA depends on the timely diagnosis of the disease, early treatment with DMARDs, appropriate assessment of the significance of symptomatic therapy, and tight control of the results of therapy with the timely correction of treatment.

References

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