HEPATIC STEATOSIS AND INSULIN RESISTANCE IN CHRONIC HEPATITIS C


如何引用文章

全文:

详细

At present, hepatic steatosis and insulin resistance are recognized as a factors of progression of chronic hepatitis C, which may be metabolic (metabolic syndrome), and viral origin (infection with genotype 3 HCV). It is important that hepatic steatosis and insulin resistance significantly impair the results of antiviral therapy for chronic hepatitis C. In this regard, treatment of hepatic steatosis and correction of insulin resistance are essential mechanisms for prevention of rapid progression of chronic hepatitis C and increase of frequency of sustained virologic response to antiviral therapy.

参考

  1. Ciuffreda D, Kim AY. Update on hepatitis C virus-specific immunity. Curr Opin HIV AIDS 2011;6(6):559-65.
  2. Persico M, Iolascon A. Steatosis as a co-factor in chronic liver diseases. World J Gastroenterol 2010;16(10):1171-76.
  3. Björnsson E, Angulo P. Hepatitis C and steatosis. Arch Med Res 2007;38(6):621-27.
  4. Patel JH, Cobbold JF, Thomas HC, Taylor-Robinson SD. Hepatitis C and hepatic steatosis. QJM 2010;103(5):293-303.
  5. Negro F. Mechanisms and significance of liver steatosis in hepatitis C virus infection. World J Gastroenterol 2006;12(42):6756-65.
  6. Jacobson IM, Davis GL, El-Serag H, et al. Prevalence and challenges of liver diseases in patients with chronic hepatitis C virus infection. Clin Gastroenterol Hepatol 2010;8(11):924-33.
  7. Khan M, Jahan S, Khaliq S, et al. Interaction of the hepatitis C virus (HCV) core with cellular genes in the development of HCV-induced steatosis. Arch Virol 2010;155(11):1735-53.
  8. Ascione A, Tartaglione T, Di Costanzo GG. Natural history of chronic hepatitis C virus infection. Dig Liver Dis 2007;39(Suppl. 1):4-7.
  9. Bondini S, Younossi ZM. Non-alcoholic fatty liver disease and hepatitis C infection. Minerva Gastroenterol Dietol 2006;52(2):135-43.
  10. Straub BK, Schirmacher P. Pathology and biopsy assessment of non-alcoholic fatty liver disease. Dig Dis 2010;28(1):197-202.
  11. Negro F. Hepatitis C virus-induced steatosis: an overview. Dig Dis 2010;28(1):294-99.
  12. El-Zayadi AR. Hepatic steatosis: a benign disease or a silent killer. World J Gastroenterol 2008;14(26):4120-26.
  13. Machado MV, Cortez-Pinto H. Insulin resistance and steatosis in chronic hepatitis C. Ann Hepatol 2009;8(Suppl. 1):67-75.
  14. Patel K, Zekry A, McHutchison JG. Steatosis and chronic hepatitis C virus infection: mechanisms and significance. Clin Liver Dis 2005;9(3):399-410.
  15. Romero-Gómez M. Hepatitis C and insulin resistance: steatosis, fibrosis and non-response. Rev Esp Enferm Dig 2006;98(8):605-15.
  16. Harrison SA. Steatosis and chronic hepatitis C infection: mechanisms and significance. Clin Gastroenterol Hepatol 2005;3(10 Suppl. 2):92-6.
  17. Zekry A, McHutchison JG, Diehl AM. Insulin resistance and steatosis in hepatitis C virus infection. Gut 2005;54(7):903-6.
  18. Arrese M, Riquelme A, Soza A. Insulin resistance, hepatic steatosis and hepatitis C: a complex relationship with relevant clinical implications. Ann Hepatol 2010; 9(Suppl.):112-18.
  19. Basaranoglu M, Basaranoglu G. Pathophysiology of insulin resistance and steatosis in patients with chronic viral hepatitis. World J Gastroenterol 2011;17(36):4055-62.
  20. Trpkovic A, Stokic E, Radak D, et al. Chronic hepatitis C, insulin resistance and vascular disease. Curr Pharm Des 2010;16(34):3823-29.
  21. Adinolfi LE, Restivo L, Zampino R, et al. Metabolic alterations and chronic hepatitis C: treatment strategies. Expert Opin Pharmacother 2011;12(14):2215-34.
  22. Puri P, Sanyal AJ. Role of obesity, insulin resistance, and steatosis in hepatitis C virus infection. Clin Liver Dis 2006;10(4):793-819.
  23. Ahn J, Flamm SL. Hepatitis C therapy: other players in the game. Clin Liver Dis 2011;15(3):641-56.
  24. Jiang D. Care of chronic liver disease. Prim Care 2011;38(3):483-98.
  25. Eslam M, Kawaguchi T, Del Campo JA, et al. Use of HOMA-IR in hepatitis C. J Viral Hepat 2011;18(10):675-84.
  26. Kawaguchi T, Sata M. Importance of hepatitis C virus-associated insulin resistance: therapeutic strategies for insulin sensitization. World J Gastroenterol 2010;16(16):1943-52.
  27. Douglas MW, George J. Molecular mechanisms of insulin resistance in chronic hepatitis C. World J Gastroenterol 2009;15(35):4356-64.
  28. Castera L, Chouteau P, Hezode C, et al. Hepatitis C virus-induced hepatocellular steatosis. Am J Gastroenterol 2005;100(3):711-15.
  29. Sheikh MY, Choi J, Qadri I, et al. Hepatitis C virus infection: molecular pathways to metabolic syndrome. Hepatology 2008;47(6):2127-33.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Bionika Media, 2012
##common.cookie##