INCLUSION OF THE BISMUTH AND ESOMEPRAZOLE IN THE TRIPLE ERADICATION THERAPY: A SIMPLE WAY TO INCREASE THE EFFECTIVENESS OF TREATMENT


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The article considers the results of clinical study which enrolled 36 patients (15 men and 21 women) with erosive ulcerative lesions of stomach and duodenum, associated with Helicobacter pylori, who were treated within 10 days with esomeprazole 20 mg 2 times a day + amoxicillin 1000 mg 2 times daily + clarithromycin 500 mg 2 times a day + bismuthate tripotassium dicitrate 240 mg 2 times a day. In addition, the comparison group included 32 patients with exacerbation of duodenal ulcer disease associated with H. pylori, treated with classic triple eradication first line therapy: omeprazole + amoxicillin + clarithromycin for 7 days. The effectiveness of eradication therapy in the study group and control group was 94.4 and 71.8% respectively. The findings indicate improving the efficiency of classical scheme of first-line eradication therapy with inclusion bismuth preparation (quadrupletherapy) and esomeprazole as a basic proton pump inhibitor, and the prolongation of treatment up to 10 days. This scheme can be recommended as first-line therapy, especially in a population of individuals with high Helicobacter pylori resistance to clarithromycin.

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