Spazmoliticheskaya terapiya sindroma razdrazhennogo kishechnika, osnovannaya na printsipe dokazatel'noy meditsiny


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Abstract

The article considers Rome III diagnostic criteria for irritable bowel syndrome (IBS). The principles of classification of IBS are discussed; data on its epidemiology and pathophysiological aspects are presented. From the standpoint of evidence-based medicine, current approaches to the treatment of IBS are considered. It is emphasized that spasmolytics were and remain the mainstay of treatment for IBS. Their use is rational for not only relief of intestinal spasms, but also for effect on visceral hypersensitivity, a one of the major pathogenetic mechanisms syndrome, by reducing the sensitivity of nociceptors.

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