Farmakoepidemiologiya i gospital'nye iskhody infarkta miokarda s pozitsiy gendernykh razlichiy


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Retrospective study of medical records of all patients who lived in the service area of Syktyvkar outpatient department № 3 and were treated at the SI “Cardiologic dispensary" of Komi Republic from 2003 to 2010 with a diagnosis of myocardial infarction (MI) was performed. The study included 1071 patients, 46.3% of women; mean age - 63,7 ± 12,8 years. In average, women were 9 years older than men (70,2 and 61,0 years, p < 0,0001) and they more often had comorbidities; as adjusted for age, they had no increased risk of in-hospital mortality compared with men. Only main groups of drugs were used in the treatment; women often required diuretic and antiarrhythmic therapies. It was noted that в-blockers, angiotensin-converting enzyme (ACE) inhibitors, and calcium antagonists have a protective properties irrespective of sex. The use of thrombolysis has not significantly reduced in-hospital mortality only in men under 75 years old and women under 65 years old; benefits of thrombolytic therapy (TLT) was not revealed in the older age groups. This study of MI patients identified protective role of в-blockers, ACE inhibitors, and calcium antagonists regardless of sex; advantages of TLT in MI patients - men over 75 and women over 65 years old - was not proven.

Full Text

Restricted Access

References

  1. Оганов Р. Г. Профилактика сердечнососудистых заболеваний в России: успехи, неудачи, перспективы // Терапевтический архив 2004. № 6. С. 22-4.
  2. Самородская И.В. Сердечно-сосудистая заболеваемость и факторы риска сердечно-сосудистых событий в РФ // Кардиоваскулярная терапия и профилактика 2005. № 3. С. 94-101.
  3. Chiamvimonvat V, Sternberg L. Coronary artery disease in women. Can Fam Physician 1998;44:2709-17.
  4. Frishman WH, GombergMaitland M, Catanese J, FuriaPalazzo S, et al. Differences between male and female patients with regard to baseline demographics and clinical outcomes in the asymptomatic cardiac ischemia (ACIP) trial. Clin Cardiol 1998;3:184-90.
  5. Семакина С.В., Сайгитов Р.Т., Глезер М.Г. Клинико-анамнестические и лабораторноинструментальные характеристики инфаркта миокарда и ранний постгоспитальный прогноз заболевания у мужчин и женщин // Проблемы женского здоровья 2010. № 2. С. 12-21.
  6. Braunwald E, Zipes PD, Libby P, Bonow RO. Heart disease: 7 ed. 2005;1-27;1951-65.
  7. Murphy B, Worcester M, Higgins R, et al. Causal attributions for coronary heart disease among female cardiac patients. J Cardiopulm Rehabil 2005;25(3):135-43.
  8. Devon HA, Zervic JJ. Symptomes of acute coronary syndromes: Are there gender differences? A review of the literature. Heart Lung 2002;31(4):235-45.
  9. Collins L, Douglas PS. Acute coronary syndromes. In Douglas PS (ed): Cardiovascular Health and Disease in Women.2nd ed. Philadelphia, WB Saunders, 2002;316-42.
  10. Hanratty B, Lawlor DA, Robinson MB. Sex differences in risk factors, treatment and mortality after acute myocardial infarction: an observational study. J Epidemiol Community Health 2000;54(12):912-16.
  11. Schoenberg NE, Peters JC, Drew EM. Unraveling the mysteries of timing: women's perceptions about time to treatment for cardiac symptoms. SocSci Med 2003;56(2):271-84.
  12. Champney KP, Frederick PD, Bueno H, et al. and the NRMI Investigators. The joint contribution of sex, age and type of myocardial infarction on hospital mortality following acute myocardial infarction. Heart 2009;95(11):895-99.
  13. Национальные рекомендации по лечению ОКС без стойкого подъема ST на ЭКГ // Кардиоваскулярная терапия и профилактика 2006. № 5. Прил. 1.
  14. Национальные рекомендации по диагностике и лечению больных острым инфарктом миокарда с подъемом сегмента ST ЭКГ // Кардиоваскулярная терапия и профилактика 2007. № 6(8). Прил. 1.
  15. Fibrinolytic Therapy Trialists' (FTT) Collaborative Group. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. Lancet 1994;343: 311-22.
  16. White HD, Barbash GI, Califf RM, et al. Age and outcome with contemporary thrombolytic therapy. Results from the GUSTO-I trial. Circulation 1996;94:1826-33.
  17. Gitt AK, Zahn, Weinberger H, et al. Thrombolysis for acute myocardial infarction in patients older than 75 years: lack of benefit for hospital mortality but improvement of long-term mortality: results of the MITRA and MIR registries (abstr). J Am Coll Cardiol 2001;37(A):648A.
  18. Stenestrand U, Wallentin L. Register of Information and Knowledge About Swedish Heart Intensive Care Admissions (RIKS-HIA). Fibrinolytic therapy in patients 75 years and older with ST-segmentelevation myocardial infarction: one-year follow-up for large prospective cohort. Arch Intern Med 2003;163:965-71.
  19. Thiemann DR, Coresh J, Schulman SP, et al. Lack of benefit for intravenous thrombolysis in patients with myocardial infarction who are older than 75 years. Circulation 2000;101:2239-46.
  20. Sobkowicz B, Lenartowska L, Nowak M, et al. Trends in the incidence of the free wall cardiac rupture in acute myocardial infarction. Observational study: experience of a single center. Academiae Medicae Bialostocensis 2005;50:161-65.
  21. Maxwell C. Women and coronary disease. Res Cardiol 1998;93:79-84.
  22. Trappolini M, Chillotti FM, Rinaldi R. Sex differences in incidence of mortality after acute myocardial infarction. Ital Heart J 2002;7:759-66.
  23. Fiebach NH, Viscoli CM, Horwitz RI. Differences between women and men in survival after myocardial infarction. Biology or methodology? JAMA 1990;263(8):1092-96.
  24. Kindwall KE. Therapy for coronary heart disease in women. Cardiovasc Clin 1989;19(3): 195-203.
  25. Levey AS, Bosch JP, Lewis JB, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999; 130:461-70.
  26. National Kidney Foundation. K/DOQI Clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 2002;39(1):SI-266.
  27. Тавлуева Е.В. Гендерные особенности формирования и прогноз инфаркта миокарда с подъемом сегмента ST. Автореферат диссертации на соискание ученой степени доктора медицинских наук. Кемерово, 2012.
  28. Еремина О.А. Гендерные и возрастные аспекты выбора реперфузионной терапии и прогноз при инфаркте миокарда с подъемом сегмента ST. Дисс. канд. мед. наук. Кемерово, 2012.
  29. Vaccarino V, Krumholz HM, Yarzebski J, et al. Sex differences in 2 year mortality after hospital discharge for myocardial infarction. Ann Intern Med 2001;134(3):173-81.
  30. Yip HK, et al. Cardiac Rupture Complicating Acute Myocardial Infarction in the Direct Percutaneous Coronary Intervention Reperfusion Era. Chest 2003;124:565-71.
  31. Зелтынь-Абрамов Е. М. Тромболитическая терапия и разрывы сердца в остром периоде инфаркта миокарда. Дисс. докт. мед. наук. М., 2011.
  32. Тавровская А.В., Качесова А.А., Соколова О.А. и др. Инфаркт миокарда: тромболизис, госпитальная летальность, разрывы миокарда // Вестник аритмологии 2008. № 51.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2012 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies