Kompleksnoe obezbolivanie pri revmaticheskikh zabolevaniyakh


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Abstract

Symptomatic analgesic therapy is an essential component of antirheumatic therapy. The article presents the review of studies on pain relief in rheumatic diseases. As a first-line treatment, non-steroidal anti-inflammatory drugs (NSAIDs) combining the analgesic, anti-inflammatory and antipyretic effects should be considered. Among these, well tolerated drugs, such as nimesulide, have advantages. Combination with tramadol and paracetamol allows to enhance the analgesic effect of NSAIDs. The presence of clinically severe muscle spasm in the pathogenesis of acute and chronic pain is an indication for the use of muscle relaxants (e.g., tizanidine), which have an intrinsic analgesic effect and the ability to enhance the analgesic effects of other analgesics.

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A. E Karateev

References

  1. Ревматология. Клинические рекомендации / Под ред. Е.Л. Насонова. М., 2010, 752 с.
  2. Насонов Е.Л., Насонова В.А. Фармакотерапия боли: взгляд ревматолога // Consilium medicum 2000. Т. 2. № 12. С. 7-14.
  3. Боль (практическое руководство для врачей) / Под ред. Н.Н. Яхно, М.Л. Кукушкина. М., 2012. 512 c.
  4. Nuesch E., Dieppe P., Reichenbach S., et al. All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study. BMJ 2011;342:d1165. doi: 10.1136/bmj.d1165.
  5. Tsuboi M., Hasegawa Y., Matsuyama Y., et al. Do musculoskeletal degenerative diseases affect mortality and cause of death after 10 years in Japan? J Bone Miner Metab 2011; 29(2):217-23.
  6. Zhu K., Devine A., Dick I., Prince R. Association of back pain frequency with mortality, coronary heart events, mobility, and quality of life in elderly women. Spine 2007;32(18):2012-18.
  7. Arboleya L., de la Figuera E., Soledad Garcia M., Aragon B. Management pattern for patients with osteoarthritis treated with traditional nonsteroidal anti-inflammatory drugs in Spain prior to introduction of Coxibs. Curr Med Res Opin 2003;19(4):278-87.
  8. Gore M., Sadosky A., Leslie D., et al. Therapy Switching, Augmentation, and Discontinuation in Patients with Osteoarthritis and Chronic Low Back Pain. Pain Pract 2012;12(6):457-68.
  9. Чичасова Н.В. Проблема боли при остеоартрозе // Леч. врач 2007. № 2. С. 18-25.
  10. Bianchi M., Martucci C., Ferrario P., et al. Increased Tumor Necrosis Factor-a and Prostaglandin E2 Concentrations in the Cerebrospinal Fluid of Rats with Inflammatory Hyperalgesia: The Effects of Analgesic Drugs. Anest Analg 2007; 104:949-54.
  11. McCrory C., Fitzgerald D. Spinal prostaglandin formation and pain perception following thoracotomy: a role for cyclooxygenase-2. Chest 2004; 125(4): 1321 -27.
  12. Tassorelli C., Greco R., Sandrini G., et al. Central components of the analgesic/antihyperalgesic effect of nimesulide: studies in animal models of pain and hyperalgesia. Drugs 2003;63(Suppl. 1):9-22.
  13. Dembo G., Park S., Kharasch E. Central nervous system concentrations of cyclooxygen-ase-2 inhibitors in humans. Anesthesiology 2005; 102(2):409-15.
  14. Каратеев А.Е., Яхно Н.Н., Лазебник Л.Б. и др. Применение нестероидных противовоспалительных препаратов. Клинические рекомендации. М., 2009. 167 с.
  15. Барскова В.Г. Письмо редактора // Соврем. ревматол. 2011. № 2. С. 82-3.
  16. Mattia C., Ciarcia S., Muhindo A., et al. 25 years later. Minerva Med 2010;101(4):285-93.
  17. Насонов Е.Л. Эффективность и переносимость нестероидного противовоспалительного препарата. Нимесулид: новые данные // РМЖ 2001. №15. С. 6-8.
  18. Rainsford K. Current status of the therapeutic uses and actions of the preferential cyclo-oxygenase-2 NSAID, nimesulide. Inflammopharmacology 2006;14(3-4):120-37.
  19. Bennett A. Nimesulide a well established cyclo-oxygenase-2 inhibitor with many other pharmacological properties relevant to inflammatory diseases. In: Therapeutic Roles of Selective COX-2 Inhibitors. Ed. J.R. Vein, R.M. Botting. William Harvey Press:524-40.
  20. Bradbury F. How important is the role of the physician in the correct use of a drug? An observational cohort study in general practice. Int J Clin Pract 2004; 144(Suppl.):27-32.
  21. Conforti A., Leone R., Moretti U., et al. Adverse drug reactions related to the use of NSAIDs with a focus on nimesulide: results of spontaneous reporting from a Northern Italian area. Drug Safety 2001;24:1081-90.
  22. Laporte J., Ibanez L., Vidal X., et al. Upper gastrointestinal bleeding associated with the use of NSAIDs: newer versus older agents. Drug Safety 2004;27:411-20.
  23. Helin-Salmivaara A., Virtanen A., Veslainen R., et al. NSAID use and the risk of hospitalisation for first myocardial infarction in the general population: a national case-control study from Finland. Eur Heart 2006;27:1657-63.
  24. Каратеев А.Е. Российский опыт применения нимесулида: обзор клинических испытаний // Consilium medicum 2011. Т. 13. № 9. С. 89-95.
  25. Каратеев А.Е., Алексеева Л.И., Братыгина Е.А., Аширова Т.Б. Оценка частоты развития побочных эффектов при длительном применении нимесулида в реальной клинической практике // РМЖ 2009. Т. 17. № 21. С. 1466-72.
  26. Каратеев А.Е., Насонова В.А. Развитие и рецидивирование язв желудка и двенадцатиперстной кишки у больных, принимающих нестероидные противовоспалительные препараты: влияние стандартных факторов риска // Тер. архив 2008. № 5. С. 62-6.
  27. Fitzcharles M., Lussier D., Shir Y. Management of chronic arthritis pain in the elderly. Drugs Aging 2010;27(6):471-90.
  28. Ong C., Seymour R., Lirk P., Merry A. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain. Anesth Analg 2010;110(4):1170-79.
  29. Pavelka K., Peliskova Z., Stehlikova H., et al. Intraindividual differences in pain relief and functional improvement in osteoarthritis with diclofenac or tramadol. Clin Drug Investig 1998; 16(6):421 -29.
  30. O'Donnell J., Ekman E., Spalding W., et al. The effectiveness of a weak opioid medication versus a cyclo-oxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug in treating flare-up of chronic low-back pain: results from two randomized, double-blind, 6-week studies. J Int Med Res 2009;37(6):1789-802.
  31. Cepeda M., Camargo.F, Zea C., Valencia L. Tramadol for osteoarthritis: a systematic review and metaanalysis. J Rheumatol 2007;34(3):543-55.
  32. Emkey R., Rosenthal N., Wu S., et al. Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial. J Rheumatol 2004;31(1):150-56.
  33. Beebe F., Barkin R., Barkin S. A clinical and pharmacologic review of skeletal muscle relaxants for musculoskeletal conditions. Am J Ther 2005;12(2):151-71.
  34. Richards B., Whittle S., van der Heijde D., Buchbinder R. The Efficacy and Safety of Muscle Relaxants in Inflammatory Arthritis: A Cochrane Systematic Review. J Rheumatol 2012;90(Suppl.):34-9.
  35. Richards B., Whittle S., van der Heijde D., Buchbinder R. Efficacy and Safety of Neuromodulators in Inflammatory Arthritis: A Cochrane Systematic Review. J Rheumatol 2012;90(Suppl.): 28-33.
  36. Richards B., Whittle S., van der Heijde D., Buchbinder R. Efficacy and Safety of Antidepressants in Inflammatory Arthritis: A Cochrane Systematic Review J Rheumatol 2012;90(Suppl.):21 -7.
  37. van Tulder M., Touray T., Furlan A., et al. Muscle relax ants for non-specific low back pain. Cochrane Database Syst Rev 2003;(2): CD004252.
  38. Berry H., Hutchinson D. A multicentre placebo-controlled study in general practice to evaluate the efficacy and safety of tizanidine in acute low-back pain. J Int Med Res 1988; 16(2):75-82.
  39. Berry H., Hutchinson D. Tizanidine and ibuprofen in acute low-back pain: results of a double-blind multicentre study in general practice. J Int Med Res 1988;16(2):83-91.
  40. Sirdalud Ternilin Asia-Pacific Study group. Efficacy and gastroprotective effects of tizanidine plus diclofenac versus placebo plus diclofenac in patients with painful muscle spasm. Curr Ther Res 1998;59:13-22.
  41. Pareek A., Chandurkar N., Chandanwale A., et al. Aceclofenac-tizanidine in the treatment of acute low back pain: a double-blind, doubledummy, randomized, multicentric, comparative study against aceclofenac alone. Eur Spine J 2009;18(12):1836-42.

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