Antiagregantnaya terapiya u patsientov s sakharnym diabetom, perenesshikh mozgovoy insul't


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Abstract

Prevention of stroke and recurrent cerebrovascular events is the actual problem of modern medicine. Diabetes mellitus increases the risk of stroke by 2-4 times. Atherothrombosis is one of the key points for the development of stroke, and the presence of diabetic throm-bocytopathy and angiopathy accelerates the formation of blood clots. According to the European Stroke Association recommendations, antiplatelet (antiaggregant) therapy is the first line of prevention of this disease. As reported by international studies, clopidogrel is the drug of choice in high-risk patients, including patients with diabetes mellitus.

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References

  1. Суслина ЗА, Варакин Ю.Я., Верещагин Н.В. Сосудистые заболевания головного мозга. Эпидемиология. Основы профилактики. 2006. 256 с.
  2. Дедов И.И, Шестакова М.В., Аметов А.С. и др. Проект "Консенсус совета экспертов Российской ассоциации эндокринологов по инициации и интенсификации сахароснижающей терапии сахарного диабета 2 типа. “Сахарный диабет". М., 2011.
  3. Pahor M, Psaty BM, Furberg CD. New evidence on the prevention of cardiovascular events in hypertensive patients with type 2 diabetes. J Cardiovasc Pharmacol 1998;32(2): S18-S23.
  4. Stamler J, Vaccaro O, Neaton JD, Wentworth D. Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 1993;16:434-44.
  5. Jokl R, Colwell JA. Arterial thrombosis and atherosclerosis in diabetes. Diabetes Metab Rev 1997;5:1-15.
  6. Алгоритмы специализированной медицинской помощи больным сахарным диабетом / Под ред. Дедова И.И., Шестаковой М.В. Изд. 4-е, доп. 4-й выпуск. М., 2009.
  7. De La Cruz JP Arrebola MM, Villalobos MA, et al. Influence of glucose concentration on the effects of aspirin, ticlopidine and clopidogrel on platelet function and platelet-subendothelium interaction. Eur J Pharmacol 2004; 484(1):19-27.
  8. Bhatt D, Marso S, Hirsch A, et al. Amplified benefit of clopidogrel versus aspirin in patients with diabetes mellitus. Am J Cardiol 2002;90:625-628.
  9. Mehta S, Yusuf S, Peters R, et al. Effects of pretreatment with clopidogrel and aspirin followed by long.term therapy in patients undrgoing percutaneous coronary intervention: the PCI.CURE study. Lancet 2001;358:527-33.
  10. Всероссийское научное общество кардиологов. Лечение острого коронарного синдрома без стойких подъемов сегмента ST на ЭКГ. Российские рекомендации // Кардиология 2001. № 10 (приложение). С. 1-23.
  11. The Clopidogrel in Unstable Angina to Prevent Recurrent Events trial investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. New Engl J Med 2001;345: 494-502.
  12. Foster CJ, Prosser DM, Agans JM, et al. Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs. J Clin Invest 2001;107:1591-98.
  13. CAPRIE Steering Committee: A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996;348:1329-39.
  14. Парфенов В.А. Вторичная профилактика ишемического инсульта // РМЖ. 2005. Т 13. № 25. С. 819-23.
  15. Ишемическая болезнь сердца и сахарный диабет: алгоритм диагностики, профилактики и лечения.Пособие для врачей / Под ред. И.И. Дедова. М., 2007.
  16. Преображенский Д.В., Сидоренко Б.А., Батыралиев Т.А. и др. Тиенопиридины в лечении и профилактике сердечно-сосудичстых заболеваний. Часть III. Терапевтическое применение клопидогрела в качестве монотерапии (без ацетилсалициловой кислоты) // Кардиология. 2009. № 12. С. 63-67.
  17. Добровольский А.В. Клопидогрел в лечении заболеваний сердечно-сосудистой системы // РМЖ. 2009. № 8. С. 558-69.
  18. Скворцова В.И., Чазова Е.И., Стаховская Л.В. Вторичная профилактика инсульта. М., 2002. 120 с.
  19. Инсульт: диагностика, лечение, профилактика / Под ред. З.А. Суслиной, М.А. Пирадова. М., 2008.
  20. Талаева Т.В., Корниенко О.В., Братусь В.В. и др. Атерогенная модификация липопротеинов крови и гиперхолестеринемия как следствия острого воспалительного процесса // Журнал АМН Украины. 1997. № 3. С. 463-71.
  21. Суслина З.А., Танашян М.М., Умарова Р.М. Клопидогрел при ишемических цереброваскулярных заболеваниях // Лечение нервных болезней. 2003. № 4. С. 14-18.
  22. PROGRESS collaborative group. Randomized trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischemic attack. Lancet 2001;358:1033-41.
  23. Staessen JA, Fagard R, Thijs L, et al. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet 1997;350:757-64.
  24. Forette F, Seux ML, Staessen JA, et al. Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial. Lancet 1998;352: 1347-51.
  25. Forette F, Seux ML, Staessen JA, et al. Systolic Hypertension in Europe Investigators. The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study. Arch Intern Med 2002;162(18):2046-52.
  26. Bennett CL, Connors JM, Carwile JM et al. Thrombotic thrombocytopenic purpura associated with clopidogrel. N Engl J Med 2000;342:1773-77.
  27. Colwell JA, Nesto RW. The Platelet in Diabetes. Diabetes Care 2003;26:2181-88.
  28. Laakso M. Epidemiology of Diabetic Dyslipidemia. Diabetes Rev 1995;3:408-22.
  29. Steiner G. The dyslipoproteinemias of diabetes. Atherosclerosis 1994;110:S27-S33.
  30. Гусев Е.И., Скворцова В.И., Стаховская Л.В. и др. Эпидемиология инсульта в России // Consilium medicum. 2003. Т. 5. № 5.
  31. Jones M, McEwan P, Morgan L-C, et al. Evaluation of the pattern of treatment, level of anticoagulation control, and outcome of treatment with warfarin in patients with nonvalvar atrial fibrillation: a record linkage study in a large British population Heart 2005;91:472-77. doi: 10.1136/hrt.2004.042465
  32. Wittkowsky AK, Boccuzzi SI, Wogen J, et al. Frequency of concurrent use of warfarin with potentially interacting drugs. Pharmacotherapy 2004;24(12):1668-74.
  33. Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. Brit Med J 2002;324:71-86.
  34. Bhatt DL, Topol EJ. Scientific and therapeutic advances in antiplatelet therapy. Nature Rev 2003;2(1):15-28.
  35. Танашян М.М., Суслина З.А., Ионова В.Г. и др. Состояние функции эндотелия у больных с ишемическим инсультом при различной степени атеросклеротического поражения сонных артерий // Неврологический вестник. 2007. Т. XXXIX. Вып. 1. С. 12-16.
  36. http://www.eso-stroke.org
  37. http://www.who.int/en/
  38. Кукес В.Г. Клиническая фармакология. М., 2004. С. 464-71.
  39. Serebruany VL, Malinin AI, Ziai W, et al. Effects of clopidogrel and aspirin in combination versus aspirin alone on platelet activation and major receptor expression in patients after recent ischemic stroke: for the Plavix Use for Treatment of Stroke (PLUTO-Stroke) trial. Stroke 2005;36(10):2289-92.
  40. Meyer DM, Albright KC, Allison TA, Grotta JC. LOAD: a pilot study of the safety of loading of aspirin and clopidogrel in acute ischemic stroke and transient ischemic attack. J Stroke Cerebrovasc Dis 2008;17(1):26-9.
  41. Kennedy J, Hill MD, Ryckborst KJ, et al.; FASTER Investigators. Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial. Lancet Neurol 2007;6(11):961-69.
  42. Jagroop IA, Matsagas MI, Geroulakos G, Mikhailidis DP. The effect of clopidogrel, aspirin and both antiplatelet drugs on platelet function in patients with peripheral arterial disease. Platelets 2004;15(2):117-25.
  43. Cassar K, Ford I, Greaves M, Bachoo P, Brittenden J. Randomized clinical trial of the antiplatelet effects of aspirin-clopidogrelcombination versus aspirin alone after lower limb angioplasty. Br J Surg 2005;92(2):159-65.
  44. Smout JD, Mikhailidis DP, Shenton BK, Stansby G. Combination antiplatelet therapy in patients with peripheral vascular bypass grafts. Clin Appl Thromb Hemost 2004;10(1):9-18.

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