OSTEOARTROZ I OSTEOARTRIT - OT NOVYKh VZGLYaDOV V PATOGENEZE K NOVOMU NAZVANIYu
- Authors: Khitrov N.A1
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- Issue: No 3s (2013)
- Pages: 53-58
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/280321
- ID: 280321
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Abstract
The article presents the data on the pathogenesis and clinical manifestation of osteoarthrosis (OA); underlying mechanisms of development of OA include both inflammatory processes and degeneration of joint tissues. The features of synovitis in OA according to data of ultrasound examination are presented. The treatment of OA of the knee in the acute phase using meloxicam and Compligam V is described. Good clinical results indicating reduction of pain and swelling, increase of range of motion, and good tolerability of the drug were achieved.
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References
- Ревматические болезни: Рук. для врачей / Под ред. В.А. Насоновой, Н.В. Бунчука. М., 1997. С. 385-96.
- Raisz LG. Prostaglandins and bone: physiology and pathophysiology. Osteoarthritis Cartilage 1999;79:83-94.
- Laufer S, Gay S, Brune K. Inflammation and Rheumatic Diseases: The molecular basis of novel therapies. Georg Thieme Verlag, 2003:139.
- Grushko G, Schneiderman R, Maroudas A. Some biochemical and biophysical parameters for the study of the pathogenesis of osteoarthritis: a comparison between the processes of aging and degeneration in human hip cartilage. Connec Tissue Res 1989;19:149-76.
- Ревматология: национальное руководство /Под ред. Е.Л. Насонова, В.А. Насоновой. М., 2008. С. 573-88.
- Hedbom E, Huselmann HJ. Molecular aspects of pathogenesis in osteoarthritis: the role of inflammation. Cell Mol Life Sci 2002;59:45-53.
- Pickvance EA, Oegema TR Jr, Thompson RC. Immunolocalization of selected cytokines and proteases in canine articular cartilage after transarticular loading. J Orthop Res 1993; 113:313-23.
- Agarwal S, Long P, Seyedain A, et al. A central role for the nuclear factor-kB pathway in antiinflammatory and proinflammatory actions of mechanical strain. FASEB J 2003;17:899-901.
- Насонов Е.Л., Каратеев А.Е. Применение нестероидных противовоспалительных препаратов. Клинические рекомендации // РМЖ2006. Т. 14. № 25. С. 1769-77.
- Feldman M, McMahon AT. Do cyclooxygenase-2 inhibitors provide benefits similar to those of traditional nonsteroidal anti-inflammatory drugs, with less gastrointestinal toxicity? Ann Intern Med 2000;132:134-43.
- Цветкова Е.С., Панасюк Е.Ю., Иониченок Н.Г., Рубцов О.В. Перспективы применения ингибиторов циклооксигеназы-2 при остеоартрозе // Consilium medicum 2004. Т. 6. № 2. С. 100.
- Каратеев А.Е., Барскова В.Г. Критерии выбора нестероидного противовоспалительного препарата // Справочник практического врача 2007. Т. 5. № 5. С. 13-7.
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