No 3s (2013)

This article analyzes the prevalence, causes, and the main clinical manifestations of non-dementing cognitive impairments -a syndrome, which is a clinical manifestation of many physical, neurological and psychiatric disorders. The diagnostic approach and the possibility of differential diagnosis are discussed in detail. The basic principles of treatment of mild cognitive disorders are presented; potentials for the use of several classes of drugs with presumable neuroprotective action are also discussed.

The article considers the complex issues of noncompliance in the treatment of chronic mental illness with an emphasis on the patient's motivation and behavioral aspects. The continuum of behavioral models of treatment compliance - from full failure to abuse - is discussed. The recommendations for overcoming of noncompliance during motivational therapy are presented.

The use of amphetamine/methamphetamine-type stimulants occurs widely in the population of schizophrenic patients. The article presents an analysis of the pathogenesis, clinical features, and the comparative effectiveness of different antipsychotic treatments of psychosis induced by psychoactive substances in schizophrenic patients. The data on the spectrum of cognitive impairments in schizophrenic patients with substance use compared to patients with schizophrenia without a history of substance use are presented. The data obtained provide more evidence of the similarity of the neurobiological mechanisms of schizophrenia and the effects of use of psychoactive substances. Management of mental disorders induced by amphetamine/methamphetamine-type stimulants remains underinvestigated.

The article describes the main principles of an integrated approach to the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in children and adolescents. The basic forms and variants of the clinical picture are characterized. The principles of the provision of medical and rehabilitation care, psychocorrection approaches and methods of the behavior modification for children are discussed. The main groups of drugs used for the specific treatment of ADHD are presented. The authors paid attention to the need for a detailed diagnostic examination in order to clarify the type, form and variant of the disease.

The article presents the data on the pathogenesis and clinical manifestation of osteoarthrosis (OA); underlying mechanisms of development of OA include both inflammatory processes and degeneration of joint tissues. The features of synovitis in OA according to data of ultrasound examination are presented. The treatment of OA of the knee in the acute phase using meloxicam and Compligam V is described. Good clinical results indicating reduction of pain and swelling, increase of range of motion, and good tolerability of the drug were achieved.