GIPOGLIKEMII V PATOGENEZE SERDEChNO-SOSUDISTOGO RISKA


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

The review article examines the relationship of hypoglycemia with cardiovascular risk as a central issue in a personalized approach to the treatment of type 2 diabetes mellitus. Randomized clinical trials define hypoglycemia as a major factor of cardiovascular mortality. The article analyzes possible mechanisms triggered by hormonal imbalance: extension and increase in the dispersion of the QT interval, cardiac autonomic neuropathy, heart rate variability, hypokalemia, prothrombotic blood potential, and markers of subclinical vascular inflammation. The choice of antidiabetic drugs with incretin actions as the most safe drugs in terms of induction of hypoglycemia, even for the elderly patients and for urgent cardiac situations, is justified.

Толық мәтін

Рұқсат жабық

Авторлар туралы

L. Ruyatkina

D. Ruyatkin

G. Berezovskaya

Әдебиет тізімі

  1. Hess K. Marx N, Lehrke M. Cardiovascular disease and diabetes: the vulnerable patient. European Heart Journal 2012;14(Suppl. B): 4-13.
  2. Inzucchi SE, et al. Лечение гипергликемии при диабете 2 типа: подход, ориентированный на пациента. Заявление о позиции Американской Диабетической Ассоциации (ADA) и Европейской Ассоциации по изучению диабета (EASD). Diabetes Care 2012;35:68-96.
  3. Desouza C, Bolli GB, Fonseca V. Hypoglycemia, Diabetes, and Cardiovascular Events. Diabetes Care 2010;33(6)1389-94.
  4. Finfer S. Hypoglycemia in critically ill adults -association yes, causation not proven. Crit Care 2011;15(6):1012.
  5. Terry T, et al. Does aggressive glycemic control benefit macrovascular and microvascular disease in type 2 diabetes? Insights from ACCORD, ADVANCE, and VADT. Curr Cardiol Rep 2012;14(1):79-88.
  6. Zoungas S, et al. ADVANCE Collaborative Group. N Engl J Med 2010;363(15):1410-18.
  7. Adler GK, et al. Antecedent hypoglycemia impairs autonomic cardiovascular function: implications for rigorous glycemic control. Diabetes 2009;58(3):360-66.
  8. Finfer S, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009;360:1283-97.
  9. Kosiborod M, et al. Glucometrics in patients hospitalized with acute myocardial infarction: defining the optimal outcomes-based measure of risk. Circulation 2008;117:1018-27.
  10. Gruden G, et al. Severe hypoglycemia and cardiovascular disease incidence in type 1 diabetes: the EURODIAB Prospective Complications Study. Diabetes Care 2012;35(7):1598-604.
  11. Stettler C, et al. Glycemic control and macrovascular disease in types 1 and 2 dibetes mellitus: Meta-analysis of randomized trials. Am Heart J 2006;152:27-38.
  12. Kitsios K, Tsapas A, Karagianni P. Glycemia and cardiovascular risk: challenging evidence based medicine. Hippokratia 2011;15(3):199-204.
  13. Rana O, et al. Acute hypoglycemia decreases myocardial blood flow reserve in patients with type 1 diabetes mellitus and in healthy humans. Circulation 2011;124(14):1548-56.
  14. Robinson RT, et al. Changes in cardiac repolarization during clinical episodes of nocturnal hypoglycaemia in adults with Type 1 diabetes. Diabetologia 2004;47(2):312-15.
  15. Marques JL, et al. Altered ventricular repolarization during hypoglycaemia in patients with diabetes. Diabet Med 1997;14(8):648-54.
  16. Veglio M, et al. The clinical utility of QT interval assessment in diabetes. Diabetes Nutr Metab 2000;13(6):356-65.
  17. Heller SR. Abnormalities of the electrocardiogram during hypoglycaemia: the cause of the dead in bed syndrome? Int J Clin Pract 2002;129(Suppl.):27-32.
  18. Лаптев Д.Н., Шмушкович И.А. Аритмогенный эффект гипогликемии // Сахарный диабет 2012. № 1. С. 25-30.
  19. Murphy NP, et al. Prolonged cardiac repolarisation during spontaneous nocturnal hypogly-caemia in children and adolescents with type 1 diabetes. Diabetologia 2004;47(11):1940-47.
  20. Yue DT, Herzig S, Marban E. Beta-adrenergic stimulation of calcium channels occurs by potentiation of high-activity gating modes. Proc Natl Acad Sci USA 1990;87(2):753-57.
  21. Christensen TF, et al. QT interval prolongation during spontaneous episodes of hypoglycaemia in type 1 diabetes: the impact of heart rate correction. Diabetologia 2010;53(9):2036-41.
  22. Busui R.P. Cardiac autonomic neuropathy in diabetes. Diabetes Care 2010;33:434-41.
  23. Vinik AI, et al. Diabetic autonomic neuropathy. Diabetes Care 2003;26:1553-79.
  24. Vlcek M, et al. Heart rate variability and catecholamines during hypoglycemia and orthostasis. Auton Neurosci 2008;143:53-7.
  25. Weston PJ, Gill GV. Is undetected autonomic dysfunction responsible for sudden death in Type 1 diabetes mellitus? The 'dead in bed'syndrome revisited. Diabet Med 1999;16(8):626-31.
  26. Ewing DJ, et al. Autonomic neuropathy, QT interval lengthening, and unexpected deaths in male diabetic patients. Diabetologia 1991;34(3):182-85.
  27. Ройтберг Г.Е., Струтынский А.В. Внутренние болезни. Сердечно-сосудистая система. М., 2007. 856 с.
  28. Koivikko ML, et al. Effects of sustained insulin-induced hypoglycemia on cardiovascular autonomic regulat ion in type 1 diabetes. Diabetes 2005;54(3):744-50.
  29. Dagogo-Jack SE, Craft S, Cryer PE. Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus. Recent antecedent hypoglycemia reduces autonomic responses to, symptoms of, and defense against subsequent hypoglycemia. J Clin Invest 1993;91(3):819-28.
  30. Segel S.A. Paramore DS, Cryer PE. Hypoglycemiaassociated autonomic failure in advanced type 2 diabetes. Diabetes 2002;51(3):724-33.
  31. Trovati M, et al. Studies on mechanisms involved in hypoglycemia-induced platelet activation. Diabetes 1986;35(7):818-25.
  32. Grant PJ et al. Hormonal control of haemostasis during hypoglycaemia in diabetes mellitus. Thromb Haemost 1987;57(3):341-44.
  33. Falcon C, et al. The platelet insulin receptor: detection, partial characterization, and search for a function. Biochem Biophys Res Commun 1988;157:1190-96.
  34. Wright RJ, et al. Effects of Acute Insulin-Induced Hypoglycemia on Indices of Inflammation. Diabetes Care 2010;33(7):1591-97.
  35. Oishi K, et al. Ketogenic diet disrupts the circadian clock and increases hypofibrinolytic risk by inducing expression of plasminogen activator inhibitor-1. Arterioscler Thromb Vasc Biol 2009;29(10):1571-77.
  36. Deacon CF, Mannucci E, Ahren B. Glycaemic efficacy of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors as add-on therapy to metformin in subjects with type 2 diabetes-a review and metaanalysis. Diabetes Obes Metab 2012;14(8): 762-67.
  37. Nauck MA, et al. Efficacy and safety of the dipeptidyl peptidase-4-inhibitor, sitagliptin, compared with sulfonylurea, glipizide in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, dooble-blind, non-inferiority trial. Diabetes Obes Metab 2007;9:194-205.
  38. Квиткова Л.В., Еленская Т.С., Благовещенская О.П. Влияние инсулинорезистентности и нарушений углеводного обмена на течение острого периода инфаркта миокарда // Проблемы эндокринологии 2011. № 2. С. 9-13.
  39. Hage C, et al. Sitagliptin improves beta-cell function in patients with acute coronary syndromes and newly diagnosed glucose abnormalities: the BEGAMI study. J Intern Med 2013;Jan 19.

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