NEDOSTATOChNOST' MAGNIYa - DOSTOVERNYY FAKTOR RISKA KOMORBIDNYKh SOSTOYaNIY: REZUL'TATY KRUPNOMASShTABNOGO SKRININGA MAGNIEVOGO STATUSA V REGIONAKh ROSSII

Maintaining of physiological magnesium levels in the tissues is a fundamental condition determining human health. A numerous of experimental and clinical studies have suggested a relationship between magnesium deficiency and the risk of various diseases and pathological conditions. The combined effect of magnesium deficiency on the etiopathogenesis of comorbid diseases is of particular interest. Multi-center, observational study «Screening of magnesium levels in the blood plasma and red blood cells in a multi-field hospital settings» was focused on the evaluation of this impact. The primary objective of the study was to determine the frequency of magnesium deficiency in various categories of patients. Large-scale screening program for prevalence of magnesium deficiency included 2,000 patients 18-90 years old, for each of which information on 187 parameters was collected. The study was conducted in four centers with participation of patients from 6 cities: Vladimir, Ivanovo, Kemerovo, Kostroma, Moscow and Ufa, including those with cardiovascular, gastrointestinal, hematological, neurological diseases (150 patients), nephrological, urological, pul-monological, dermatological, gynecological and endocrinological abnormalities ( 150 patients). The study also included 500 healthy volunteers. Data on medical history diagnosis, demographics, anthropometric parameters, data of blood test (evaluation of magnesium levels in plasma and red blood cells), and urinalysis were registered. The study included patients admitted to the hospital for emergency care or for planned treatment. Low magnesium levels ( <0.8 mmol/L in plasma) was detected in 956 patients, while a high levels (> 1.3 mmol/L) - only in 70 patients, which indicates a high prevalence of magnesium deficiency It is shown that magnesium deficiency corresponds to significantly increased risk of conditions such as E66.3. Overweight, G47.8. Sleep disorders, R56.8. Cramps, H52. Myopia, I63.0. Ischemic cerebral infarction, I10. Essential primary hypertension, I34.1. Mitral valve prolapse, F43.0. Acute stress reaction, I20.0. Unstable angina, N94.3. Premenstrual syndrome, E11.7 E11.8. Insulin-dependent diabetes mellitus, I47.9. Paroxysmal tachycardia, etc. Data of analysis of pyridoxine level using structured questionnaire in patients showed that 47% of patients did not have any deficit, and severe deficit was found only in 16% of patients. Most severe pyridoxine deficiency corresponded to lower magnesium levels (correlation coefficient, r=-0,53). It is shown that the optimal serum magnesium level with the minimum risk of diagnoses studied, ranged 0.80 to 0.85 mmol/L. The plasma magnesium levels up to 0.80 mmol/L correspond to a statistically significant increased risk of the above and other pathologies. Results of the study support the use of medicines containing organic magnesium salts for the replenishment and prevention of its deficiency

magnesium, magnesium deficiency, screening, pyridoxine, comorbid conditions