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Amplification or overexpression of human epidermal growth factor receptor 2 (HER2) is observed in approximately 25 % of cases of breast cancer (BC). Trastuzumab is a recombinant humanized monoclonal antibody against HER2, which is effective as monotherapy and improves the results of chemotherapy for HER2-positive metastatic and resectable breast cancer. The article presents the results of phase I-II study of trastuzumab-DMI (T-DM1),a new immunoconjugate of monoclonal antibodies, and maytansinoid DM1 (ADC) in patients with ER2 + metastatic BC.

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参考

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