NOVYY IMMUNOMODULYaTOR REFNOT V LEChENII ONKOLOGIChESKIKh BOL'NYKh
- Authors: Kadagidze Z.G1, Slavina E.G1, Abramov M.E1, Vyshinskaya G.V1, Darenskaya A.D1
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- Issue: No 8 (2013)
- Pages: 71-74
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/281252
- ID: 281252
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Abstract
The new domestic immunomodulator Refnot is a combination of a recombinant tumor necrosis factor a and thymosin-α1. The article presents the results of studies on the application of Refnot as a monotherapy and in combination with chemotherapy in a number of malignant tumors (mainly in disseminated melanoma of the skin) in 55 patients who have exhausted the possibilities of a standard drug treatment. Efficacy of monotherapy with Refnot (stable disease) was 28 %. Disease control against the background of treatment with Refnot in combination with chemotherapy was achieved in 54,5% of cases. It has been shown that Refnot has a positive impact on anti-tumor immunity. Unlike other known immunomodulators this drug simultaneously positively influence the two cell populations -T-lymphocytes and NK-cells, which are major components of antitumor immunity.
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