Vyrazhennost' kislotosupressivnogo deystviya ingibitorov protonnoy pompy i effektivnost' sovremennykh eradikatsionnykh skhem


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Abstract

In many Western countries, Japan and Australia, a trend toward reduction in the incidence of peptic ulcer disease and noncardiac gastric cancer, directly correlated with a decrease in the prevalence of Helicobacter pylori infection in the population, is observed. Almost three decades of practical application of antihelicobacter therapy, a hundreds of clinical studies and more than 100 meta-analyses of controlled studies clearly suggest that there is no guarantee of success, regardless of the chosen regimen of treatment. This article considers the significance of the antisecretory treatment in eradication schemes, are discusses the prospects for improvement of efficacy of antihelicobacter therapy by increasing doses of proton pump inhibitors.

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About the authors

Yu. A Kucheryavyy

Email: proped@mail.ru

E. V Barkalova

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