Genital'nyy endometrioz


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The study was aimed to the evaluation aim of the short-term and long-term results of treatment of endometriosis (EM) in patients receiving therapy with triptorelin and levonorgestrel-releasing intrauterine system (LNG-IUS). The study involved 37 women aged 20 to 45 years. Pain in the lower abdomen and lumbar region was the common complaint; 27 women reported dysmenorrhea; there were 16 infertile patients. Prolonged release form of triptorelin was administered intramuscularly 1 time a month at a dose of 3.75 mg; LNG-IUS was injected into the uterus for the prevention of recurrence of EM. Evaluation of the effectiveness was performed during 4 years. Examination of 21 patients after 6-12 months and 4 years after the introduction of LNG-IUS into the uterus had no revealed cases of recurrence of EM; at the same time, the side effects of triptorelin («hot flashes», vaginal dryness, emotional lability, moderate insomnia, ostealgia), as a rule, became less pronounced or disappeared, which was considered as a remission of EM. 7 patients after treatment with triptorelin became pregnant. The results lead to the following conclusion: the combination therapy of EM using triptorelin and LNG-IUS prevents relapse of EM, prevents side effects and enhances therapeutic effects of triptorelin.

Full Text

Restricted Access

About the authors

R. A Manusharova

Email: diogenis@rambler.ru

References

  1. Адамян Л.В., Андреева Е.Н. Генитальный эндометриоз: этиопатогенез, клиника, диагностика, лечение. М., 2001.
  2. Сидорова И.С., Коган Е.А., Унанян А.Л. Эндометриоз тела матки и яичников, М., 2007. - 30 с.
  3. Адамян Л.В., Кулаков В.И. Эндометриозы. М., 1998.
  4. Стрижаков А.Н., Давыдов А.И. Эндометриоз: клинические и терапевтические аспекты. М., 1996.
  5. Thomas E.J., Cooke I.D. Impact of gestrinone on the course of asymptomatic endometriosis // Brit. Med. J. - 1987. - Vol. 294. - P. 272-74.
  6. Mahmood T.A, Templeton A. The impact of treatment on the natural history of endometriosis // Hum. Reprod. - 1990. - Vol. 5. -P. 965-70.
  7. Сметник В.П., Тумилович Л.Г. Неоперативная гинекология, М., 2005.
  8. Манушарова Р.А., Черкезова Э.И. Лечение эндометриоза аналогом гонадотропин-рилизинг-гормона // Фарматека. - 2004. - № 1. - С. 40-3.
  9. Манушарова Р.А., Черкезова Э.И. Применение аналогов гонадотропин-рилизинг-гормона при гормонально зависимых заболеваниях. М., 2005. - С. 27.
  10. Леонов Б.В., Кулаков В.И., Корнеева И.Е. и др. Применение агониста гонадотропин-рилизинг-гормона Диферелина при бесплодии // Акушер. и гинекол. - 2002. -№ 4. - С. 1-4.
  11. Волков Н.И., Камилова Д.П., Корнеева И.Е. Эффективность Диферелина при комбинированном лечении больных с бесплодием и миомой матки // Акушер. и гинекол. - 2002. - № 3. - С. 49-50.
  12. Манушарова Р.А., Черкезова Э.И. Комплексная терапия аденомиоза индинолом и эпигаллатом. XIV Российский национальный конгресс «Человек и лекарство» / Сб. материалов конгресса (тезисы докладов) 16-20.04. 2007. М., 2007. - С. 242.
  13. Pakarinen P., Labteenmaki P., Rutanen E. The effect of intrauterine and oral levonorgestrel administration on serum concentrations of sex hormone - binding globulin, insulin and insulin -like growth factor - binding protein - 1 // Acta Obstet. Gynaecol. - 1999. - Vol. 78(5). -P. 423-28.
  14. Nilsson C.G., Lahteenmaki P., Luukkainen T. Ovarian function in amenorrheic and menstruating users of a levonorgestrel-releasing intrauterine device // Fertil.Steril. - 1984. - Vol. 41. - P. 52-5.
  15. Barbosa J., Bakos O., Olsson S.E., et al. Ovarian function during use of a levonorgestrel - releasing IUD // Contraception. - 1990. - Vol. 42. - P. 51-66.
  16. Mchley H., Wang H., Kelly R., et al. Progestin receptor isoforms and prostaglandin dehydrogenase in the endometrium of women using a levonorgestrel - releasing intrauterine system // Hum. Reprod. - 1998. - Vol. 13(5). -P. 1210-710.
  17. Прилепская В.Н. Внутриматочная контрацепция. М., 2000.
  18. Simon C., Gutierres A.,Vidal A., et al. Outcome of patients with endometriosis in assisted reproduction: results from in vitro fertilization and oocyte donation // Hum. Reprod. - 1994. -Vol. 9. - P. 725-29.
  19. Fedele L., Bianchi S., Raffaelli R., et al. Treatment of adenomyosis - аssociated menorragia with a levonorgestrel releasing intrauterine device // Fertil Steril. - 1997. - Vol. 68. - P. 426-29.
  20. Vercellini A., Aimi G., Panazza S., et al. опухолевых клеток путем усиления прооксидантной активности. Levonorgestrel-releasing intrauterine system for the treatment of dysmenorrhea associated with endometriosis: a pilot study // Fertil Steril. - 1999. - Vol. 72. - P. 505-08.
  21. Barrington J.W., Bowen-Simpkins F. Management of refractory pre-menstrual syndroms using subcutaneous oestradiol implants and levonorgestrel intrauterine systeme // Br. J. Obstet. Gynecol. - 1997. - Vol. 104. -P. 614-16.
  22. Johansson E. Future aspects of the levonorg-estrel - releasing intrauterine system // Gynecol. Forum. - 1998. - Vol. 3(3). - P. 311-32.
  23. Robinson G.E., Bounds W., Kubba A.A., et al. Functional ovarian cysts associated with levonorgestrel - releasing intrauterine device // Brit. J. Fam. Plann. - 1989. - Vol. 14. -P. 131-32.
  24. Brosens I.A., Puttemans P.J. Double-optic laparoscopy. Salpingoscopy, ovarian cystoscopy, and endoovarian surgery with the argon laser // Baillieres Clin. Obstet. Gynecol. -1989.- Vol. 3. -P. 595-608.
  25. Heaps J.M., Berek J.S., Nieberg R.K. Malignant neoplasms arising in endometriosis // Obstet. Gynecol. - 1990. - Vol. 75. - P. 1023-28.
  26. Sutton C.J. G., et al. A comparison between the CO2 and KTP lasers in the treatment of large ovarian endometriomas // Gynaecol. Endoscopy. - 1993. - Vol. 2. - P. 113-18.
  27. Olive D.L., Lee K.L. Analysis of sequential treatment protocols for endometriosis-associated infertility//Am.J. Obstet. Gynecol. - 1986.- Vol. 154. - P. 613-19.
  28. Dmowski W.P., Friberg J., Rana N., et al. The effect of endometriosis, its stage and activity, and of autoantibodies on in vitro fertilization and embryo transfer success rates // Fertil Steril. -1995. - Vol. 63. - P. 555-62.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2013 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies