Primenenie tsefiksima v pediatricheskoy praktike


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The article presents a review of clinical studies analyzing the effectiveness of cefixime, semisynthetic III generation cephalosporin for oral use. The data of meta-analysis of the efficacy of a 10-day course of various cephalosporins compared with penicillin for streptococcal throat infection in children are presented. The evidence base for the treatment effectiveness of cefixime in urinary tract infections in children is considered. The article summarizes the experience of Russian and foreign clinical research showing that cefixime is highly effective and safe antibacterial drug. The fact that cefixime is administered once a day is essential for pediatric practice, and has a positive effect on the treatment compliance.

Full Text

Restricted Access

References

  1. Справочник по антимикробной терапии / Под ред. Р.С. Козлова, А.В. Дехнича. Вып. 3. Смоленск, 2013. 480 с.
  2. Страчунский Л.С., Козлов С.Н. Современная антимикробная химиотерапия. Руководство для врачей. М., 2002. 432 с.
  3. Гучев И.А., Рафальский В.В., Мелехина Е.В. Роль цефиксима в терапии обострения хронической обструктивной болезни легких. Клиническая микробиология и антимикробная химиотерапия. 2008; 10: 270-82.
  4. Bisno A.L. Acute pharyngitis. N. Engl. J. Med. 2001; 344(3): 205-11.
  5. Linder J.A., Bates D.W., Lee G.M., Finkelstein J.A. Antibiotic treatment of children with sore throat. JAMA. 2005; 294(18): 2315-22.
  6. Spinks A.B., Glasziou P.P., Del Mar C.B. Antibiotics for sore throat. Cochrane Database Syst. Rev. 201; 18: CD000023.
  7. Шпынев К.В., Кречикова О.И., Кречиков В.А., Козлов Р.С. Streptococcus pyogenes: характеристика микроорганизма, выделение, идентификация и определение чувствительности к антибактериальным препаратам. КМАХ. 2007; 9(2): 104-19.
  8. Kozlov R., Sivaja O. Antimicrobial resistance of S. pyogenes in Russia: results of prospective multicentre study PEHASus - 17th European Congress of Clinical Microbiology and Infectious Diseases ICC, Munich, Germany, 31 Mar - 04 Apr 2007 - abstract number: 1733-255.
  9. Баранов А.А., Богомильский М.Р., Волков И.К. и др. Применение антибиотиков у детей в амбулаторной практике: практические рекомендации. КМАХ. 2007; 9(3): 200-10.
  10. Насонова В.А., Белов Б.С., Страчунский Л.С. и др. Антибактериальная терапия стрептококкового тонзиллита и фарингита. КМАХ. 1999; 1: 78-82.
  11. Gerber M.A., Baltimore R.S., Eaton C.B., et al. Prevention of Rheumatic Fever and Diagnosis and Treatment of Acute Streptococcal Pharyngitis: A Scientific Statement From the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young, the Interdisciplinary Council on Functional Genomics and Translational Biology, and the Interdisciplinary Council on Quality of Care and Outcomes Research: Endorsed by the American Academy of Pediatrics. Circulation. 2009; 119: 1541-51.
  12. Bisno A.L., Gerber M.A., Gwaltney J.M. Jr., et al. Practice guidelines for the diagnosis and man-agementof group A streptococcal pharyngitis. Infectious Diseases Society of America. Clin. Infect. Dis. 2002; 35(2): 113-25.
  13. Gastanaduy A.S., Kaplan E.L., Huwe B.B., et al. Failure of penicillin to eradicate group A streptococci during an outbreak of pharyngitis. Lancet. 1980; 6(2): 498-502.
  14. Pichichero M.E., Marsocci S.M., Murphy M.L., et al. Incidence of streptococcal carriers in private pediatric practice. Arch. Pediatr. Adolesc. Med. 1999; 153(6): 624-28.
  15. Brook I. The role of beta-lactamase-producing bacteria in the persistence of streptococcal tonsillar infection. Rev. Infect. Dis. 1984; 6(5): 601-07.
  16. Brook I., Foote P.A. Efficacy of penicillin versus cefdinir in eradication of group A streptococci and tonsillar flora. Antimicrob. Agents Chemother. 2005; 49(11): 4787-88.
  17. Casey J.R., Pichichero M.E. Meta-analysis of cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis in children. Pediatrics. 2004; 113(4): 866-82.
  18. Altamimi S., Khalil A., Khalaiwi K.A., et al. Short versus standard duration antibiotic therapy for acute streptococcal pharyngitis in children. Cochrane Database Syst. Rev. 2009; 21(1): CD004872.
  19. Adam D., Hostalek U., Tröster K. 5-day therapy of bacterial pharyngitis and tonsillitis with cefixime. Comparison with 10 day treatment with penicillin V. Klin. Padiatr. 1996; 208(5): 310-13.
  20. Геппе Н.А., Дронов И.А., Малявина У.С., Афонина Е.Ю. Применение цефиксима для эмпирической терапии внебольничных инфекций дыхательных путей у детей. Педиатрия. 2010; 6: 108-13.
  21. Козлов Р.С., Сивая О.В., Шпынев К.В. и др. Антибиотикорезистентность Streptococcus pneumoniae в России в 1999-2005 гг.: результаты многоцентровых проспективных исследований ПеГАС-I и ПеГАС-II. Клин. микробиол. антимикроб. химиотер. 2006; 8: 33-47.
  22. Jacobs M.R., Felmingham D., Appelbaum P.C., et al. The Alexander Project 1998-2000: susceptibility of pathogens isolated from community-acquired respiratory tract infection to commonly used antimicrobial agents. J. Antimicrob. Chemother. 2003; 52: 229-46.
  23. Harrison C.J., Woods C., Stout G., et al. Susceptibilities of Haemophilus influenzae, Streptococcus pneumoniae, including serotype 19A, and Moraxella catarrhalis paediatric isolates from 2005 to 2007 to commonly used antibiotics. J. Antimicrob. Chemother. 2009; 63: 511-19.
  24. Pichichero M.E., Doern G.V., Kuti J.L., Nicolau D.P. Probability of achieving requisite pharmacodynamic exposure for oral beta-lactam regimens against Haemophilus influenzae in children. Paediatr. Drugs. 2008; 10: 391-97.
  25. Hedrick J.A. Community-acquired upper respiratory tract infections and the role of third-generation oral cephalosporins. Expert. Rev. Anti. Infect. Ther. 2010; 8: 15-21.
  26. Harrison C.J., Chartrand S.A., Pichichero M.E. Microbiologic and clinical aspects of a trial of once daily cefixime compared with twice daily cefaclor for treatment of acute otitis media in infants and children. Pediatr. Infect. Dis. J. 1993; 12: 62-9.
  27. Gooch W.M. 3rd, Philips A., Rhoades R., et al. Comparison of the efficacy, safety and acceptability of cefixime and amoxicillin/clavulanate in acute otitis media. Pediatr. Infect. Dis. J. 1997; 16(2 Suppl): 21-4.
  28. Середа Е.В., Катосова Л.К., Волков И.К. Эффективность цефалоспорина III поколения цефиксима (супракса) при заболеваниях органов дыхания у детей. Леч. врач. 2004; 1: 31-4.
  29. Балясинская Г.Л., Борисова Е.М. Пероральные цефалоспорины 3 поколения в лечении острых инфекционно-воспалительных заболеваний ЛОР-органов у детей раннего возраста. Педиатрия. 2009; 87: 89-91.
  30. Коровина Н.А., Захарова И.Н., Страчунский Л.С. и др. Практические рекомендации по антибактериальной терапии инфекций мочевой системы внебольничного происхождения у детей: пособие для врачей. 2002. 21 с.
  31. Паунова С.С. Инфекция мочевой системы у детей (этиология, патогенез, клиника). Медицинский научный и учебнометодический журнал. 2002; 9: 56-72.
  32. Цыгин А.Н., Комарова О.В., Сергеева Т.В. и др. Инфекция мочевыводящих путей // Клинические рекомендации: Педиатрия / Под ред. А.А. Баранова. М., 2005. С. 81-96.
  33. Barry A.L., Jones R.N. Cefixime: spectrum of antibacterial activity against 6,016 clinical isolates // Pediatr. Infect. Dis. J. 1987; 6(10): 954-57.
  34. Ляхова О.А., Остроумова М.В., Галкин В.В. и др. Чувствительность возбудителей инфекций мочевыводящих путей к цефиксиму. Лечащий врач. 2008; 8: 89-91.
  35. Sanchez Merino J.M., Guillan Maquieira C., Fuster Foz C., et al. Evolution of Escherichia coli antibiotic resistances in urine samples from the community. Arch. Esp. Urol. 2008; 61(7): 776-80.
  36. Francois P., Croize J., Bost C., Wollschlager K. Comparative study of cefixime versus amoxicillin-clavulanic acid combination in the oral treatment of urinary tract infections in children. Arch. Pediatr. 1995; 2(2): 136-42.
  37. Hoberman A., Wald E.R., Hickey R.W., et al. Oral versus initial intravenous therapy for urinary tract infections in young febrile children. Pediatrics. 1999; 104(1): 79-86.
  38. Gok F., Duzova A., Baskin E., et al. Comparative study of cefixime alone versus intramuscular ceftizoxime followed by cefixime in the treatment of urinary tract infections in children. J. Chemother. 2001; 13(3): 277-80.
  39. Benador D., Neuhaus T.J., Papazyan J.P., et al. Randomised controlled trial of three day versus 10 day intravenous antibiotics in acute pyelonephritis: effect on renal scarring. Arch. Dis. Child. 2001; 84(3): 241-46.
  40. Lettgen B., Tröster K. Prophylaxis of recurrent urinary tract infections in children. Results of an open, controlled and randomized study about the efficacy and tolerance of cefixime compared to nitrofurantoin. Klin. Padiatr. 2002; 214(6): 353-58.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2014 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies